Rebuilding the Infarcted Heart

Summary

Revascularization of the heart is the prime objective following a myocardial infarction as the morbidity inflicted severely impacts the patient's lifestyle and working capabilities. The use of stem cell transplantation is one route that is receiving considerable funding from government and private sources. This book examines the various methods available that will help the patient to recover from the adverse effects of a myocardial infarction. It takes the reader from bench to bedside, from chalk to dust, and explains in clear detail how the mechanisms of stem cell transplantation work.

Contents

• Molecular Basis of Cardiac Growth and Regeneration
• Origins of Cardiac Differentiation and Morphogenesis
• Cardiac Regeneration in Lower Species
• Post-Natal Cardiomyogenic Stem Cells within The Mammalian Heart
• Is There Evidence for Adult Cardiomyogenic Stem Cells outside The Heart in Mammals?
• Pre-Clinical Studies of Myocardial Repair
• Myocardial Regeneration via Cell Cycle Activation
• Mesenchymal Stem Cell Therapy for The Injured Heart
• Myocardial Regeneration via Intra-Cardiac Stem Cells? Myocardial Regeneration via Embryonic Stem Cell-Derived Cardiomyocytes and Therapeutic Cloning
• Stem Cells and Vascular Regeneration
• Cytokine Treatment for Cardioprotection and/or Cardiac Regeneration
• Early Clinical Experience with Cell Therapy
• Cell Transplantation in Chronic Heart Failure, Proof of Concept and Early Clinical Experience
• Cell Transplantation after Acute Myocardial Infarction: Current Status and Future Applications