Summary
The science of premenstrual syndrome has developed rapidly in the past decade.
The role of ovarian steroids and the hypothalamo-pituitary-ovarian axis has been partly elucidated; the science of the role of neurotransmitters has advanced, particularly the neuropeptides and especially the roles of serotonergic and GABA pathways.
Evidence-based evaluation of treatment methods is unfolding, whereas previously this was often based on anecdote and dogma. Indeed much of pharmaceutical licensing the UK particularly but also in Europe and the US has been based on such premises. The knowledge that normal ovarian function is the trigger for events in women who have an increased susceptibility to progesterone due to neurochemical changes, has made an immense difference to the understanding of PMS.
This text is definitive, scientific, readable, and offers a reference and text for specialist gynecologists, psychiatrists and psychologists working at a high level in their respective professions. It is an academic text of the highest level being authoritative and comprehensive and has;the correct balance between psychiatry and gynecology as well as an international team of European, US and UK authors.
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