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The Future of Systems Biology
Emerging technologies and their impact on drug discovery, development and diagnostics
Publication Date January 2005
Publisher Business Insights
Product Type Report
Pages 157
ISBN Number not applicable
Product Code RBI073
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Summary
This report provides a detailed insight into this complex new process and how it can be used to drive research and development in a variety of biologically-based industries. The competitive landscape of systems biology assessed in this report is supported by case studies of leading companies, enabling you to learn from their experiences and avoid the potential pitfalls. The future of pharmaceuticals lies in combination therapies and more personalized therapeutics. This report will help you to maximize the cost and time saving benefits offered by biological systems.
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Content
- Executive Summary
- Introduction To Systems Biology
- Key Aspects And Components Of Systems Biology
- Applications Of Systems Biology
- Emerging Technologies And Developments
- Case Studies And Success Stories
- Interviews With Thought Leaders In Systems Biology
- Chapter 1 Introduction To Systems Biology
- Summary
- Introduction
- Introduction To Systems Biology
- Research Applications Of Systems Biology
- The Evolution Of Systems Biology
- Mathematical Modeling
- Physiology And Cell Biology
- And Now
- Change From Reductionist Biology
- New Technologies
- Chapter 2 Key Aspects And Components Of Systems Biology
- Summary
- Introduction
- Approaches To Systems Biology
- Bottom-Up Approach
- Top-Down Approach
- The Reality In Systems Biology: A Combination Of Bottom-Up And Top-Down
- Key Aspects Of Systems Biology
- System Structures
- System Dynamics
- The Control Method
- The Design Method
- Four Basic Steps In Systems Biology
- Key Technology Components Of Systems Biology
- The "Omics"
- Genomics
- Transcriptomics
- Proteomics
- The Emerging "Omic" - Metabolomics
- Data Storage And Mining
- Bioinformatics
- Network Biology
- Pathway Analysis
- Modeling And Biosimulations
- Chapter 3 Applications Of Systems Biology
- Summary
- Introduction
- Drivers Of Systems Biology
- Increase In R&d Costs
- Examples Of How Systems Biology Can Lower Costs:
- Fall In R&d Productivity
- Drug Failures In Clinical Trials
- Systems Biology In Pharmaceutical Discovery And Development
- Identification Of Drug Targets
- Examples Of Success:
- Improving The Quality Of Lead Compounds
- Improved Admet Prediction
- Fewer Costly Failures Due To Toxicity
- Examples Of Success:
- Optimization Of Clinical Trials
- Example Of Success:
- Identification Of Biomarkers
- Biomarkers For Drug Discovery And Validation
- Examples Of Success:
- Biomarkers For Toxicity
- Biomarkers And Segmentation Of Patient Populations
- Examples Of Success:
- Biomarkers And The Fda's Critical Path Initiative
- Development Of Combination Drug Therapies
- Additional Indications For Pharmaceuticals Already On The Market
- Improved Lead Prioritization And Optimization
- Better Clinical Trials Strategies
- Regulatory/Industry Initiatives
- The Fda's Critical Path Initiative
- Examples Of Success:
- National Institutes Of Health (Nih) Roadmap
- Diagnostic Applications For Systems Biology
- Cancer
- Diagnosis Of Cancer
- Delineation Of Cancer By Sub-Groups For Therapeutic Decisions
- Monitoring Of Efficacy Of Treatment
- Examples Of Success:
- Diabetes
- Example Of Success:
- Systems Biology In Bioprocess Engineering
- Examples Of Success:
- Additional Applications For Systems Biology
- Agricultural Improvement
- Examples Of Success:
- Cosmetics
- Example Of Success:
- Biodefense
- Example Of Success:
- Bioremediation
- Examples Of Success:
- Conclusions
- Chapter 4 Emerging Technologies And Developments
- Summary
- Introduction
- Rnai
- Sirna - Small Interfering Rnas
- Mirna - Micrornas
- New Proteomic Technologies
- Antibody Arrays
- Morphoproteomics
- Time-Of-Flight Mass Spectrometry (Ms)
- Ion Trap Ms
- Maldi-Tof
- Q-Tof Ms
- Liquid Chromatography (Lc) Q-Tof Ms-Ms Spectrometer
- Emerging Software Developments
- Systems Biology Markup Language (Sbml)
- Systems Biology Workbench (Sbw)
- Celldesigner
- Cytoscape
- Pathway Tools Software From Sri
- Pathwaystudio Central
- Srs Pathway Editor From Lion Bioscience Ag
- Databases Of Interest
- Panther Database Of Proteins
- Kegg: Kyoto Encyclopedia Of Genes And Genomes
- Spad: Signaling Pathway Database
- Bind: Biomolecular Interaction Network Database
- Hprd: Human Protein Reference Database
- Go: Gene Ontology
- Dip: Database Of Interacting Proteins
- Biobase: Biological Databases / Biologische Datenbanken Gmbh
- Pdb: Protein Data Bank
- Afcs: Alliance For Cellular Signaling
- Biomodels Database
- Initiatives In Systems Biology
- International Initiatives
- E-Cell Project, Keio University, Japan
- Kitano Symbiotic Systems Project
- International Physiome Project
- Standard Metabolic Reporting Structures (Smrs)
- Virtual Cell Project - National Resource For Cell Analysis And
- Modeling
- Biospice
- Microbes Online
- European Initiatives
- Systemsx
- European Interaction Proteome
- Us Initiatives
- Biocomputation Program, Darpa
- Genomes To Life Initiative, Doe
- Metabolic Engineering Working Group, Multiple Agencies
- National Centers For Systems Biology (Ncsb), National Institute For
- General Medical Sciences (Nigms), Nih
- Key Academic Centers
- Mit's Computational And Systems Biology Institute
- Harvard University's Department Of Systems Biology
- The Center For Quantitative Biology, Princeton
- Systems Biology Group At The University Of Stuttgart, Germany
- Intelligent Bioinformatics Systems Division (Ibsd), German Cancer
- Research Center, Heidelberg, Germany
- What Is Holding System Biology Back?
- Lack Of Knowledge
- Genomic
- Proteomic
- Biomolecular Networks
- Need For Better Analytical Tools
- Lack Of Computing Power
- The Conservative Culture In Big Pharma
- Failed Promises In The Past
- Chapter 5 Case Studies And Success Stories
- Summary
- Case Studies
- Johnson & Johnson Pharmaceutical Research And Development, (J&jprd)
- Integrative Drug Discovery Using Systems Biology
- Examples Of Success:
- F. Hoffman-La Roche
- Some Software Tools Roche Uses
- Examples Of Success:
- Pfizer
- Examples Of Success:
- Lilly Systems Biology (Singapore)
- Glaxosmithkline's Scientific Computing And Mathematical Modeling
- (Scmm) Group
- Additional Success Stories
- In Silico Target Screen For Als Treatment (Harvard University)
- Creation Of Virtual Asthma Patients (Entelos/Aventis)
- Diabetes Biomarkers
- Chapter 6 Interviews With Thought Leaders In Systems Biology
- Summary
- Introduction
- 1. What Do You Feel Are Systems Biology Greatest Strengths?
- Adriano Henney
- Iya Khalil
- Karin Jorga
- 2. What Do You Feel Is Holding Back Systems Biology From Being Used More
- Widely? (Other Than A Lack Of Trained Personnel)
- Ah
- Ik
- Kj
- 3. Where Do You Feel Systems Biology Has, And Will Have, The Greatest Impact
- In Drug Discovery And Development - Now, And In Ten Years?
- Ah
- Ik
- Kj
- Dr. Iya Khalil And Dr. Karin Jorga On Success Stories
- Q. Are There Any Success Stories, Or Examples Of Successful Use Of Systems
- Biology That You Can Share?
- Ik
- Kj
- Dr. Adriano Henney Discusses How Astrazeneca Moved Into The Field Of
- Systems Biology
- Q. How Did Astrazeneca Become Involved In Systems Biology?
- Ah
- Chapter 7 Key Companies In Systems Biology
- Introduction
- Non-Profit Organizations
- Institute For Systems Biology
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Collaborations
- Patents
- Pathway Analysis
- Cellzome Ag
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Collaborations
- Patents
- Genego
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Products
- Collaborations
- Licensing Agreements
- Patents
- Hybrigenics Sa
- Hybrigenics USA
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Products / Services
- Collaborations
- Patents
- Ingenuity
- Overview
- Systems Biology Sector
- Technology
- Products
- Services
- Licensing Agreements
- Collaborations
- Patents
- Biosimulation And In Silico Modeling
- Gene Network Sciences
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Products
- Collaborations
- Licensing Agreements
- Patents
- Genomatica
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Products
- Collaborations
- Licensing Agreements
- Patents
- Kenna Technologies
- Overview
- Systems Biology Sector
- Primary Therapeutic Focus
- Technology
- Products
- Collaborations
- Patents
- Physiomics Plc
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Products
- Collaborations
- Patents
- Data Management Companies
- Genedata
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Products
- Collaborations
- Licensing Agreements
- Patents
- Genstruct
- Overview
- Systems Biology Sector
- Main Therapeutic Focus
- Technology
- Collaborations
- Licensing Agreements
- Patents
- Bg Medicine
- Overview
- Systems Biology Sector
- Primary Therapeutic Focus
- Technology
- Collaborations
- Patents
- Chapter 8 Appendix
- References
- Journals
- General References
- Overviews
- Pharmaceutical Discovery
- Target Validation
- Lead Optimization
- In Silico Modeling
- Bioinformatics
- Systems Biology For Bioprocess Engineering
- Biomarkers
- Pathways
- Some Websites Of Interest:
- Overviews:
- U.S. Government
- Index
- List Of Figures
- Figure 2.1: Basic Steps In Systems Biology
- Figure 3.2: Applications Of Systems Biology
- Figure 3.3: New Chemical Entities (Nces) Approved By Year, 1999-2004
- Figure 3.4: Drug Discovery Costs, 2003
- Figure 3.5: Causes Of Drug Failures, 2001
- List Of Tables
- Table 3.1: Time And Cost For Compound Discovery And Development
- Table 3.2: Time And Cost For Preclinical And Clinical Testing Of Lead Compounds
- Table 7.3: Key Isb Patents And Patent Applications
- Table 7.4: Key Cellzome Ag Patents
- Table 7.5: Key Genego Patent Applications
- Table 7.6: Key Hybrigenics Patents And Patent Applications
- Table 7.7: Key Ingenuity Medicine Patents And Patent Applications
- Table 7.8: Key Gns Patent Applications
- Table 7.9: Key Genomatica Patents
- Table 7.10: Key Kenna Technologies Patent
- Table 7.11: Key Physiomics Patent
- Table 7.12: Key Genstruct Patent Applications
- Table 7.13: Key Bg Medicine Patents And Applications 147
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| Scope |
Comprehensive Overview |
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| Level |
Management Strategy |
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| Data |
Broad Market Predictions |
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| Features |
Identifies Hot Technologies |
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| Extra Info |
Regulatory Guidance |
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