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The Future Of Array Technologies

Impact on drug discovery and market growth in DNA, protein and tissue arrays

Publication Date   January 2005
Publisher   Business Insights
Product Type   Report
Pages   156
ISBN Number   not applicable
Product Code   RBI072
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Price £1,495.00

approximately: $2,793 | €1,896

Summary


The study of genes used to be a slow and arduous process with a single gene studied in a single experiment. The filter and blotting methods used provided limited information about other genes or how single genes interact with the collective gene product in a living organism. The advent of DNA microarrays (also referred to as biochips, DNA chips, DNA arrays, gene arrays and GeneChips), which allow analysis of many genes in a single experiment quickly and efficiently, has transformed research. Whole genomes are now available for study on a single microarray. Recently, the same technologies have been modified and applied to the study of RNA, proteins, cells and tissue samples with promising results. The new technologies have broad applications ranging from genetic screening, diagnostics and safety assessment, to proteomics and drug development.

Content


  • Executive Summary
    • Current Array Technologies
    • Novel And Emerging Array Technologies
    • Array Applications In Drug Discovery & Development
    • The Array Market
    • Key Players - Competitor Landscape
  • Chapter 1 Current Array Technologies
    • Summary
    • Introduction
    • Dna Arrays
    • Microarray Preparation
    • Limitations And Advantages Of Dna Microarrays
    • Rna Arrays
    • Limitations And Advantages Of Rna Arrays
    • Protein Arrays
    • Expression Arrays
    • Functional Arrays
    • Reverse Arrays
    • Limitations And Advantages Of Protein Arrays
    • Tissue Arrays
    • Cell Arrays
    • Conclusions
  • Chapter 2 Novel And Emerging Array Technologies
    • Summary
    • Introduction
    • Advances In Sample Preparation
    • Laser Capture Microdissection (Lcm)
    • Microfluidics - Lab-On-A-Chip Technologies
    • Advantages And Limitations Of Microfluidics And Lab-On-A-Chip Technology
    • Applications Of Lab-On-A-Chip Devices
    • Healthcare
    • Laboratory Products
    • Companies Investing In Microfluidics
    • Chip-On-Chip
    • Applications And Commercially Available Products
    • Chromosome-On-A-Chip
    • Chromosome-On-A-Chip Preparation
    • Advantages And Applications Of Chromosome-On-A-Chip Technology
    • Commercially Available Products
    • Nanoarrays
    • Advantages Of Nanoarray Over Microarray Technology
    • Applications And Commercially Available Products
    • The Bioforce Nanosciences Nanoarrayer System
    • Nanoink's Nscriptor
    • Leading Emerging Array Technology
    • Intellectual Property (Ip) - The Patent Minefield
    • Affymetrix Ip Portfolio
    • Incyte Genomics Ip Portfolio
    • Aclara Ip Portfolio
    • Caliper Technologies Ip Portfolio
    • Nanogen Ip Portfolio
    • Oxford Gene Technology (Ogt) Ip Portfolio
    • Recent Patents
    • Nanofluidics Technology
    • Chip-On-Chip Technology
    • Conclusions
  • Chapter 3 Array Applications In Drug Discovery & Development
    • Summary
    • Introduction
    • Array Applications In Drug Discovery And Development
    • Expression Profiling
    • Gene Expression Studies In Drug Discovery
    • Protein Expression Studies In Drug Discovery
    • Expression Study Applications In Oncology
    • Expression Study Applications In Inflammatory Disease
    • Expression Study Applications In Cns
    • Expression Study Applications In Metabolic Disorders
    • Expression Study Applications In Infectious Diseases
    • Expression Study Applications In Vaccines
    • Application Of Array Technology In Target Validation
    • Future Applications Of Arrays In Drug Discovery
    • Hts
    • High Throughput Genomics
    • High Throughput Proteomics
    • Capture Arrays
    • Interaction Arrays
    • Future Applications Of Arrays In Hts
    • Toxicology Screening
    • Toxicogenomics
    • Future Applications Of Array Technology In Toxicogenomics
    • Toxicoproteomics
    • Pharmacogenomics/Proteomics
    • Pharmacogenomics
    • The First Diagnostic Array
    • The Amplichip Cyp450 Test
    • Pharmacoproteomics
    • Pharmacoproteomic Arrays
    • Pharma Alliances With Pharmacoproteomics Specialists
    • Future Applications Of Pharmacogenomics/Proteomics
    • Theranostics
    • Conclusions
    • Diagnostics
    • New Diagnostic Arrays
    • Conclusions
  • Chapter 4 The Array Market
    • Summary
    • Introduction
    • The Array Market
    • Methodology For Market Sizing And Forecasts
    • Market Size And Future Trends
    • Dna Array Market
    • Protein Array Market
    • Cell & Tissue Array Market
    • Emerging Array Technologies
    • Market Size And Future Trends Based On Application
    • Expression Profiling
    • Toxicology Screening
    • Pharmacogenomics
    • Hts Screening
    • Diagnostics
    • Conclusions
  • Chapter 5 Key Players - Competitor Landscape
    • Summary
    • Introduction
    • Major Players
    • Alliances And Acquisitions In The Dna Array Market
    • Alliances And Acquisitions In The Protein Array Market
    • Alliances And Acquisitions In The Tissue Array Market
    • Alliances And Acquisitions In The Emerging Array Technology Market
  • Chapter 6 Glossary & References
    • Glossary
    • References
    • Index
    • Website References
  • List Of Figures
    • Figure 1.1: Schematic Representation Of A Typical Dna Array Preparation
    • Figure 1.2: The Application Of Transfected Cell Array In Gene Expression
    • Figure 1.3: Schematic Representation Of A 'Sandwich'-Type Expression Array
    • Figure 1.4: Schematic Representation Of Tissue Microarray Production
    • Figure 1.5: Schematic Representation Of Cell Array
    • Figure 2.6: Laser Capture Microdissection Process
    • Figure 2.7: Lab-On-A-Chip Technology
    • Figure 2.8: Point Of Care (Poc) Lab-On-A-Chips
    • Figure 2.9: Openarray Thru-Hole Technology
    • Figure 2.10: Hplc-Chip
    • Figure 2.11: Schematic Of 10nm Chromatin Fiber
    • Figure 2.12: Schematic Overview Of Array Cgh
    • Figure 3.13: Array Technology Applications In Drug Discovery & Development
    • Figure 3.14: A Typical Gene Expression Assay
    • Figure 3.15: A Typical Differential Protein Expression Assay
    • Figure 3.16: Microarrays In Vaccine Development
    • Figure 3.17: Optimization Of Lead Compounds Using Expression Profiling
    • Figure 3.18: Comparison Of Gene Expression Profiles To Optimize Leads
    • Figure 3.19: Pmi Technology
    • Figure 3.20: Proteinchip Biology System
    • Figure 3.21: Genechip Hts System (96 Array Plate)
    • Figure 3.22: Strategies For Analysis Of Toxicogenomics/Proteomic Data
    • Figure 3.23: Snp Analysis To Predict Drug Response
    • Figure 3.24: The First Diagnostic Array - Amplichip
    • Figure 3.25: The Value Of Theranostics To Pharmaceutical Product Development & Marketing
    • Figure 3.26: Three Stages Of Diagnostic Development
    • Figure 3.27: Potential Commercial Diagnostic Markers
    • Figure 4.28: Array Market Geographical Sales Split, 2003
    • Figure 4.29: Proportion Of Sales From Array Market Segments, 2004
    • Figure 4.30: Growth In The Array Market, 2004-2015
  • List Of Tables
    • Table 1.1: Steps In The Design And Implementation Of A Dna Microarray Experiment
    • Table 1.2: Dna Microarray Applications
    • Table 1.3: A Selection Of Dna Microarray Manufacturers
    • Table 1.4: Array Capacity And Feature Size
    • Table 1.5: Rna Microarray Applications
    • Table 1.6: Commercial Rnai Libraries
    • Table 1.7: Protein Microarray Applications
    • Table 1.8: A Selection Of Protein Array Manufacturers
    • Table 1.9: Tissue Microarray Applications
    • Table 1.10: Commercial Tma Suppliers
    • Table 1.11: Tissue Imaging Systems Adapted For Tma
    • Table 1.12: Cell Microarray Applications
    • Table 1.13: Commercial Cell Array Suppliers
    • Table 2.14: Advantages And Limitations Of Microfluidics And Lab-On-A-Chip Technology
    • Table 2.15: Companies With An Interest In Microfluidics And Lab-On-A-Chip Devices
    • Table 2.16: Selected Companies Applying Nanotechnology In Designing Arrays
    • Table 2.17: Microarray Technology Patents Registered Worldwide Up To April 2005
    • Table 2.18: Recent Patent Disputes Regarding Array Technology
    • Table 3.19: Technology Platforms For Pharmacogenomic Assays
    • Table 3.20: Altered Drug Effects In Humans Due To Genetic Polymorphism And Polymorphisms Of Drug Transporters (Dt) And Receptors (R)
    • Table 3.21: Drugs Extensively Metabolized By Cyp2c19 And Cyp2d6
    • Table 3.22: Proteomic Biomarkers
    • Table 4.23: Global Sales Of Array Technologies, 2004-2015
    • Table 4.24: Application Of Array Technologies In Market Segments
    • Table 4.25: Sales Forecasts For Total Array Market, 2004-2015
    • Table 4.26: Array Sales Forecasts For Expression Profiling, 2004-2015
    • Table 4.27: Array Sales Forecasts For Toxicology Screening, 2004-2015
    • Table 4.28: Array Sales Forecasts For Pharmacogenomics, 2004-2015
    • Table 4.29: Array Sales Forecasts For Hts, 2004-2015
    • Table 4.30: Array Sales Forecasts For Diagnostics, 2004-2015
    • Table 5.31: Companies Involved In Array Technologies, A-L
    • Table 5.32: Companies Involved In Array Technologies, M-Z
    • Table 5.33: Affymetrix Strategic Alliances During The Last 2 Years
    • Table 5.34: Recent Invitrogen Genomic And Proteomic Mergers And Acquisitions
    • Table 5.35: Recent Ciphergen Strategic Alliances