Chapter 1. Executive Summary
Chapter 2. Introduction to Protein Crystallography
Protein Crystallography: The Concept
Crystallization Techniques
Crystallization Screening is a Sampling Problem
Protein Crystallography: Motif to Crystal
A Small Crystal
Protein Crystallography: An Approach to Crystallization
Protein Crystallography: Diffraction Set-Up
Protein Crystallography: Crystal to Structure
Protein Crystallography: Sample Data
Why Crystallography in Drug Design
Cost and Timeline of Drug Development
Advantages of Crystallography in Drug Design
Fundamental Protein Crystallography Challenges
Why High-Throughput Protein Crystallography Now?
Structural Genomics Progress Statistics
Caveats and Conclusions from targetDB
Both Protein Expression and Crystallization Are Comparable High-Throughput Screening Tasks
Basic Overview of High-Throughput Protein Crystallization
Extended View of High-Throughput Protein Crystallography
Customized High-Throughput Protein Crystallography Automation
An Example of Customized High-Throughput Protein Crystallography Automation
Automation and Approaches for High-Throughput Protein Crystallography
Demands on Liquid Handling in Crystallization
Basic Two-Stage Set-up—Cocktail Preparation
Second Stage: Crystallization Plate Set-up
Combination: 96+8 Innovadyne Dispenser
Multi-Purpose Batch Robot: IMPAX, ORYX
Multiple Stages Needs Plate Transfer and Storage
State of the Market, June 2004: Technology Trends—Drop Size
State of the Market, June 2004: Technology Trends—Software
Summary of Bottlenecks in the Automation of Protein Crystallography
Applications and Limitations of Protein Crystallography
Chapter 3. Interviews With Experts
Chapter 4. Market Analysis
State of the Market, June 2004: Market Trends
State of the Crystallography Space, June 2004: Market Trends
State of the Crystallography Space, June 2004: Growth Trends
Market Evolution: Qualitative Depiction
Protein Crystallography Competitive Landscape
Summary of Market Opportunities
Chapter 5. Competitive Landscape
Accelrys
ActiveSight
Astex Technology, Ltd.
Bruker Biosciences
Crystal Research
DataCentric Automation/Kendro
DeCode Genetics
Diversified Scientific
Douglas Instruments, Ltd.
Fluidigm
Formulatrix
Genomic Solutions, Inc.
Gilson
Hamilton Company
Hampton Research
Innovadyne Technologies, Inc.
Matrix Technologies
Molecular Dimensions
Oxford Diffraction
Rigaku/MSC
RoboDesign International, Inc.
Shamrock Structures
Structural GenomiX
Syrrx
Tecan AG
TriTek Corporation
TTP LabTech, Ltd.
Veeco Instruments
Appendix I. Methodology
