Technology

Applications of LC-MS in Toxicology

Publication Date June 2006
Publisher Pharmaceutical Press
Product Type Book
Pages 304
ISBN Number 0853696292
Product Code PHP050

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Price £80.00 approximately: $158 \| €102
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Summary

Following the developments of LC-MS in the last decade and its establishment as the method of choice in the pharmaceutical industry (analytical R&D), the technique has gained favour in other scientific disciplines including analytical toxicology. This is notably due to the fact that purchase and operative costs of the equipment have gradually decreased over the same period.

This report offers a review of LC-MS in the context of forensic and clinical toxicology, giving practical hands-on information on applications of the technique on different groups of drugs and poisons in different environments (clinical, forensic, etc.).

Who should buy this book:

Forensic and clinical toxicologists, analytical chemists and forensic scientists worldwide.

Key futures of the book

• Chapters provide a thorough and critical review of the literature whilst also giving much practical information and best practice advice not easily found in journal articles.
• Latest information on the development, optimisation and validation of LC-MS methods.
• This title will be of interest to purchasers of Clarke's Analysis of Drugs and Poisons 3e.

Content

1. Ionisation, Ion Separation and Ion Detection in LC-MS
2. Method Development and Optimisation of LC-MS
3. Quantification Using LC-MS
4. Method Validation Using LC-MS
5. Identification and Confirmation Criteria for LC-MS
6. Systematic Toxicological Analysis with LC-MS
7. Analysis of Therapeutic Drugs with LC-MS
8. LCMS of Drugs of Abuse and Related Compounds
9. LC-MS in Doping Control
10. Pesticide Analysis Using LC-MS
11. Peptide Analysis Using LC-MS
12. LCMS in Forensic Chemistry