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Pharmacy |
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Pharmaceutical Toxicology (ULLA)
First Edition
Publication Date June 2006
Publisher Pharmaceutical Press
Product Type Book
Pages 280
ISBN Number 0 85369 593 8
Product Code PHP054
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Summary
Before a drug substance can be tested in man, a set of toxicology studies must be carried out in animals and in vitro to ensure, as far as possible, safety for the test subjects.Toxicity studies involve assessment of acute, repeated dose and chronic toxicities, evaluation of potential effects on vital organs, reproductive and developmental toxicity studies, and carcinogenicity studies.
This book covers a limited number of areas of drug toxicity which address the major issues including registration requirements of new drugs and pharmacovigilance. It also provides an overview of the methodology and requirements of pre-clinical safety assessment of new medicines. Mechanisms by which drugs cause toxic effects in living organisms, and problems in the toxicity of specific agents are covered, as are regulatory issues, pharmacovigilence, and clinical toxicology.
Who should buy this book:
Postgraduate pharmaceutical science students, pharmaceutical scientists, regulatory, pharmaceutical and industry libraries worldwide.
Why buy this book
The ULLA series is a new and innovative series of introductory textbooks for postgraduate students in the pharmaceutical sciences.There is no other textbook at this level dedicated to pharmaceutical toxicology, and this new title in the ULLA series fills a definite gap in the market.
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Content
1. General toxicology
2. Drug metabolism: inactivation and bioactivation of xenobioptics
3. Molecular and cellular mechanisms of toxicity
4. Teratology
5. Genotoxicity
6. Carcinogenicity of drugs
7. Liver toxicity
8. Kidney toxicity
9. Toxicology in the respiratory system
10. Immunotoxicity
11. Clinical toxicology
12. Safety assessment of pharmaceuticals: regulatory aspects
13. Pharmacovigilance
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