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Executive Summary
1: TECHNOLOGY-DRIVEN METAMORPHOSIS
The drive to add value in the supply chain
Manufacturer changes
Customer changes
E-commerce and e-business: threat or opportunity?
Status of e-commerce in the pharmaceutical sector
The US experience
Drugstore.com
CVS.com (formerly Soma.com)
MyGNP.com
PlanetRx.com
Walgreen
Legal barriers to European e-commerce
The opportunities
Pharmacy advantages
Patient advantages
Wholesalers' attitudes to e-commerce
Intranet opportunities
Government initiatives and the UK's NHSnet
The threats of e-commerce
The outlook for e-commerce
Other IT services and technologies
EDI links
Collaborative planning forecasting and replenishment
Enterprise resource planning
Specialist solutions
Technology services offered by leading wholesalers
Manufacturer support services
Order fulfilment packages
Database technology
Electronic point-of-sale technology
Electronic order entry
Bar coding
Warehouse technology
Dispensing technology
Future systems
2: CROSSING EUROPEAN BORDERS
Barriers to crossborder distribution
Regulations
Differences in pharmacy regulations
Pricing and reimbursement
Local health culture
Packaging and labelling
Margins and VAT
Moves towards a single European pharmaceutical market
Regulatory harmonisation
Wholesale distribution directive
Good distribution practice
Pricing convergence
The price transparency directive
The Bangemann round table process
Future EU policy
Outlook for crossborder supply
Pan-European globalisation of wholesalers
Crossborder mergers and acquisitions
European alliances
Groupement International de la Rpartition
Pharmaceutique Europenne (GIRP)
The impact of EMU
Parallel trade
Factors encouraging parallel trade
Parallel import markets
Parallel traders
Parallel exports
Wholesaler involvement in parallel trade
Outlook for parallel trade
3: THE EUROPEAN DISTRIBUTION CHAIN
The pharmaceutical marketplace
The OTC market
Distribution of OTCs
Generics
Distribution of generics
Players and roles in the supply chain
Manufacturers
Wholesalers
Retail pharmacy
Relationships within the supply chain
The hospital sector
Prewholesaling
Direct distribution
Pharmlog
Glaxo Wellcome's agency agreement
Margins and discounts
Margins
Wholesalers' costs
Rebates and discounts
Wholesaler profitability
Levels of competition
Rationalisation
Wholesaler consolidation
Vertical integration
Pharmacy support
OTC merchandising
Training and management services
Trade channel analysis
Independent pharmacies
Pharmacy chains
Wholesaler involvement in pharmacy chains
Pharmacy purchasing groups
Supermarkets
Wal-Mart
Drugstore chains
Home care
Doctor dispensing
Alternative distribution channels
Mail-order pharmacy
Managed care involvement
New competitors in distribution
4: DISTRIBUTION MARKET PROFILES
Austria
Belgium
Czech Republic
Denmark 116
Finland
France
Germany
Greece
Hungary
Ireland
Italy
Luxembourg
Netherlands
Norway
Poland
Portugal
Slovakia
Spain
Sweden
Switzerland
UK
5: PROFILES OF LEADING WHOLESALERS
Overview
Alliance UniChem
Boots
Galenica
Gehe
OPG
Phoenix
Sanacorp
Tamro
6: FUTURE SCENARIO
Competitive environment
Crossborder distribution
E-commerce
Supplier strategies
Relationships with the trade channels
Vertical integration
GLOSSARY
List of Figures
Figure 1.1: Information flows between wholesalers, suppliers and customers
Figure 1.2: Transforming the supply chain to an e-chain
Figure 1.3: A vision of the pharma e-business supply chain
Figure 2.1: Comparative average European price indices 1998
Figure 2.2: Total pharmaceutical expenditure per capita by country 1998 (ex-factory prices)
Figure 3.1: The role of the pharmacist
Figure 3.2: Number of inhabitants per pharmacy 1998
Figure 3.3: Wholesaler concentration in European pharmaceutical markets, based on the market share of the top three wholesalers 1997
Figure 3.4: New supply chain patterns 108
Figure 5.1: Revenue of Gehe divisions 1998
List of Tables
Table 1.1: Extent of Internet trading for all industries
Table 1.2: Usage and growth in e-commerce
Table 1.3: Benefits of e-business to the supply chain
Table 1.4: Advantages and disadvantages of e-commerce for patients
Table 1.5: Examples of European wholesalers' web-based pharmacy support systems
Table 2.1: Average delays in the launch of new drugs
Table 2.2 Current pharmaceutical market distortions within 'free trade' EU
Table 2.3: Distribution margin systems in Europe 1999
Table 2.4: VAT rates in the EU 1999
Table 2.5: Recent crossborder wholesaler mergers and acquisitions
Table 2.6: European market presence of pan-European wholesalers
Table 2.7: IPSO membership
Table 2.8: Membership of Euro Pharm Logistics 1996
Table 2.9: Membership of GIRP 1999
Table 2.10: Threats and opportunities of EMU
Table 2.11: Extent of parallel imports in Europe 1997/98
Table 2.12: Leading parallel importers 1997
Table 2.13: Economic indicators of CEE EU accession candidates 1997
Table 3.1: Leading prescription pharmaceutical markets in Europe 1998
Table 3.2: European pharmaceutical markets 1997
Table 3.3: European market forecast 1998-2002
Table 3.4: European OTC sales at public prices 1997
Table 3.5: Generic incentives in Europe 1999
Table 3.6: Leading international generic companies 1997
Table 3.7: Leading generic markets in Europe
Table 3.8: Distribution routes for generics as a percentage of the total 1997
Table 3.9: Recent pharmaceutical industry mega-mergers
Table 3.10: Prescription drug share of the pharmaceutical wholesale business 1997
Table 3.11: Number of different packs sold 1997
Table 3.12: Numbers of full-line wholesalers and warehouses 1997 and 1995
Table 3.13: The dominance of pharmacies and wholesalers in European markets 1997
Table 3.14: Varying objectives within the supply chain 83
Table 3.15: Examples of wholesalers' prewholesaling divisions
Table 3.16: Advantages and disadvantages of direct distribution
Table 3.17: Net wholesaler and pharmacy trading margins 1998
Table 3.18: Average price structure in European countries as a percentage of total retail price 1998
Table 3.19: Wholesalers' average credit terms 1996
Table 3.20: Rebates (as a percentage of sales of reimbursable products, excluding
VAT) paid by pharmacists to national health insurance institutions 1996
Table 3.21: Illustration of pharmaceutical wholesaler profitability compared with other players in the supply chain 1998
Table 3.22: Wholesaler concentration in the major European pharmaceutical markets 1998
Table 3.23: Retail pharmacy structure in the UK 1998
Table 4.1: Wholesaler margins 1 February 1997
Table 4.2: Austrian pharmacy margins 1 February 1997
Table 4.3: Sick fund discounts February 1997
Table 4.4: Leading Belgian wholesalers 1996
Table 4.5: Danish pharmacy margin calculation 1998
Table 4.6: Leading wholesalers in France 1998
Table 4.7: Leading wholesalers in Germany 1999
Table 4.8: German wholesaler margins July 1998
Table 4.9: German pharmacy margins July 1998
Table 4.10: Wholesaler and pharmacy margins in Hungary 1997
Table 4.11: Wholesaler and pharmacy margins in Italy May 1997
Table 4.12: Leading distributors in the UK 1998
Table 5.1: Leading European pharmaceutical wholesalers
Table 5.2: Performance of Alliance UniChem 1994-98
Table 5.3: Alliance UniChem's international sales 1998
Table 5.4: Activities of Alliance UniChem 1998
Table 5.5: Performance of Boots 1998-99
Table 5.6: Boots' revenue by division, year ending 31 March 1999
Table 5.7: Performance of Galenica 1996-98
Table 5.8: Performance of Gehe 1997-98
Table 5.9: Structure of Gehe 1998
Table 5.10: Performance of OPG 1994-98
Table 5.11: OPG's operating divisions
Table 5.12: Performance of Phoenix 1994-99
Table 5.13: Activities of Phoenix 1998
Table 5.14: Performance of Sanacorp Pharmahandel 1997-98
Table 5.15: Activities of Sanacorp Pharmahandel
Table 5.16: Performance of Tamro 1997-98
Table 5.17: Activities of Tamro 1998
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