Hologic Medical Device Company Intelligence Report

Summary

Medical Device Company Intelligence Reports provide a full review of the company's activities, from its origins to its latest corporate activity, including mergers and acquisitions, agreements, divestitures, major purchasing contracts and litigation. Sections are included on products, international activities and R&D, as well as a full, in-depth five year financial analysis. An introduction to each report and a full table of contents is provided for review. More than 60 Medical Device Company Intelligence Reports are currently available.

Hologic develops and manufactures medical imaging systems and diagnostic and surgical products focused on the healthcare needs of women. Through several key acquisitions, the company has increased its revenues from US$288 million in 2005 to more than US$1,670 million in 2008.

Hologic has four reporting segments: Breast Health (formerly Mammography/Breast Care), Diagnostics, GYN Surgical and Skeletal Health. The Diagnostics and GYN Surgical reporting segments were previously part of Cytyc. The AEG and MammoSite operations (the latter, formerly a part of Cytyc) are now included in Breast Health, and the osteoporosis assessment, mini C-arm and magnetic resonance imaging (MRI) product lines are included in Skeletal Health.

Hologic's Breast Health business produces a portfolio of breast imaging and related products and accessories, including digital and film-based mammography systems, computer-aided detection (CAD), breast biopsy guidance systems, minimally-invasive breast biopsy and tissue extraction devices and breast brachytherapy products.

The Diagnostics product segment includes the ThinPrep System, which is primarily used in cytology applications, such as cervical cancer screening, and the FullTerm Fetal Fibronectin Test, which offers clinical benefits for the assessment of the risk of pre-term birth. Through the acquisition of Third Wave, Hologic added in vitro diagnostic devices using Third Wave's Invader technology, allowing researchers to create assays to perform hepatitis C virus genotyping, inherited disorders testing and testing for other mutations associated with genetic predispositions and other diseases such as cystic fibrosis.

The GYN Surgical business includes the NovaSure Impedance Controlled RF Ablation System, which enables physicians to treat women suffering from excessive menstrual bleeding, and the Adiana Complete Transcervical Sterilization (TCS) System, which is a form of permanent female contraception intended as an alternative to tubal ligation for which Hologic is seeking PMA from the FDA.

The Skeletal Health division includes dual-energy X-ray bone densitometry systems, an ultrasound-based osteoporosis assessment product, Fluoroscan mini C-arm imaging products and the Esaote line of extremity MRI systems that are manufactured by an original equipment manufacturer (OEM).

Headquartered in Bedford, Massachusetts, Hologic employs more than 4,000 employees worldwide. The company's common stock is listed on the Nasdaq Global Select Market.

Contents

• SUMMARY OPERATING RESULTS.iii
• OVERVIEW
  • Recent Key Events
• FINANCIAL REVIEW
  • First Quarter Fiscal 2009 Financial Results
    • Hologic - First Quarter Fiscal 2008/2009 Financial Results
    • Hologic - Q109 and Q108 Revenues and Operating Income by Business Sector
    • Hologic - Q109 and Q108 Product Sales by Geographic Area
  • 2008 Financial Results
    • Hologic - Annual Financial Results, 2004-2008
    • Hologic - Annual Revenues and Operating Income/Loss, 2004-2008
    • Hologic - Annual Revenues and Operating Income by Business Sector, 2006-2008
    • Hologic - Annual Product and Service Revenues, 2006-2008
    • Hologic - Annual Product Sales by Geographic Area, 2006-2008
    • Hologic - 2008 Sales by Geographic Area
  • Five-Year Financial Data
    • Hologic - Five-Year Financial Summary, 2004-2008 (US$ million)
  • Outlook
  • Employees
  • Hologic Employees, 2004-2008
• STRATEGIC FOCUS
• PRODUCTS
  • Breast Health Products
    • Hologic - Sales of Breast Health Products, 2006-2008
    • DirectRay Digital Detector
    • Selenia Full Field Digital Mammography System
    • Breast Tomosynthesis
    • Screen-Film Mammography Systems
    • SecurView Workstation
    • CAD Systems
    • Stereotactic Breast Biopsy Systems
    • Breast Biopsy Products
    • MammoSite Radiation Therapy System
    • MammoPad Breast Cushion
    • Photoconductor Coatings
  • Diagnostic Products
    • Hologic - 2008 Diagnostic Product Sales as a % of Total Sales
    • ThinPrep System
    • InVitro Diagnostic Devices
    • HPV Offering
  • GYN Surgical Products
    • Hologic - 2008 GYN Surgical Sales as a % of Total Sales
    • NovaSure System
    • Adiana Complete Transcervical Sterilization (TCS) System
    • GliaSite Radiation Therapy System
  • Skeletal Health Products
    • Hologic - Skeletal Health Product Sales, 2006-2008
    • QDR X-Ray Bone Densitometers
    • Sahara Clinical Bone Sonometers
    • Hologic
    • Mini C-arm Imaging
    • Extremity MRI
  • Product Approvals
    • Hologic - Recent US and European Product Approvals
• RESEARCH AND DEVELO PMENT
  • Hologic - R&D Expenses, 2004-2008
  • Cytyc R&D Projects
  • Helica Thermal Coagulator System
  • Other R&D Projects
  • Third Wave R&D Projects
• MANUFACTURING
  • Hologic - Principal Manufacturing Facilities, September 2008
• AGREEMENTS
  • Agreements Summary
• Advanced I mage Enhancement (AIE)
• Esaote
• iCAD
• Del G lobal Technologies
• Aloka
• InSiteOne
• Mammography Reporting Systems
• Agfa-Gevaert
• Siemens
  • Digital Mammography
  • X-ray Bone Densitometers
• Varian Medical Systems
• Sedecal, Stephanix and Radiologia
• Ethicon Endo-Surgery
• Caligor
• Medica
• Christie G roup of C anada
• SUPPLY AGREEMENTS
• Tromp Medical
• US Army Medical Material Agency (USAMMA)
• Novation
• Broadlane
• US Department of Veterans Affairs
• Defense Supply Center of Philadelphia
• US Department of Veterans Affairs National Acquisition Center
• HealthTrust Purchasing G roup
• MERGERS AND ACQUISITIONS
  • Mergers and Acquisitions Summary
  • Third Wave Technologies
  • Cytyc
  • BioLucent
  • Suros Surgical Systems
  • R2 Technology
  • AEG Elektrofotografie
  • Fischer I maging's Mammography Business
  • VH Services
  • US Assets of Trex Medical
  • Hologic
  • Direct Radiography
  • Fluoroscan I maging Systems
• MINORITY INVESTMENTS
  • Combinent BioMedical Systems
  • Synarc
• DIVESTITURES
  • CT CAD Technology
  • Gestiva
  • Medical Data Management Division
• LITIGATION
  • Digene
  • Ethicon Endo-Surgery
  • SenoRx
  • Tissue Extraction Devices
• KEY CORPORATE EVENTS
• Index of Tables
  • SUMMARY OPERATING RESULTS.iii
  • Recent Key Events
  • Hologic - First Quarter Fiscal 2008/2009 Financial Results
  • Hologic - Q109 and Q108 Revenues and Operating Income by Business Sector
  • Hologic - Q109 and Q108 Product Sales by Geographic Area
  • Hologic - Annual Financial Results, 2004-2008
  • Hologic - Annual Revenues and Operating Income by Business Sector, 2006-2008
  • Hologic - Annual Product Sales by Geographic Area, 2006-2008
  • Hologic - Five-Year Financial Summary, 2004-2008 (US$ million)
  • Hologic Employees, 2004-2008
  • Hologic - Recent US and European Product Approvals
  • Hologic - R&D Expenses, 2004-2008
  • Hologic - Principal Manufacturing Facilities, September 2008
  • Agreements Summary
  • Mergers and Acquisitions Summary
• Index of Charts
  • Hologic - Annual Revenues and Operating Income/Loss, 2004-2008
  • Hologic - Annual Product and Service Revenues, 2006-2008
  • Hologic - 2008 Sales by Geographic Area
  • Hologic - Sales of Breast Health Products, 2006-2008
  • Hologic - 2008 Diagnostic Product Sales as a % of Total Sales
  • Hologic - 2008 GYN Surgical Sales as a % of Total Sales
  • Hologic - Skeletal Health Product Sales, 2006-2008