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Oral Lipid-Based Formulations: Enhancing the Bioavailability of Poorly Water-Soluble Drugs


Publication Date   June 2007
Publisher   Informa Healthcare
Product Type   Book
Pages   355
ISBN Number   978-0-8247-2945-5
Product Code   IFH142
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Price £115.00

approximately: $215 | €146

Summary


Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs.

Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem of major significance, the pharmaceutical industry has been slow to apply and further develop this technology. This title provides a comprehensive summary of the theoretical and practical aspects of oral lipid-based formulations for use in industry and provides further insights into a developing technology expected to assume increasing prominence in years to come.

Content


  • Currently Marketed Oral Lipid-Based Dosage Forms: Drug Products and Excipients
  • Lipid-Based Excipients for Oral Drug Delivery
  • Feasibility Assessment for Scaling Initial Prototype Lipid- Based Formulations to Initial Phase I/Ii Clinical Trial Batches
  • Materials, Process and Manufacturing Considerations for Lipid-Based Hard Capsule Formats
  • Liquid Self-Micro-Emulsifying Drug Delivery Systems (Smedds). Lipid-Based Isotropic Solutions: Design Considerations
  • Lipid-Based Selfemulsifying Solid Dispersions
  • Using Preclinical Data to Dictate Formulation Strategies for Poorly Water-Soluble Drugs
  • Physiological Processes Governing The Gastrointestinal Absorption of Lipids and Lipophilic Xenobiotics
  • Characterizing Release from Lipid-Based Formulations
  • Using in Vitro Dynamic Lipolysis Modeling as A Tool for Exploring Ivivc Relationships for Oral Lipid-Based Formulations
  • Case Study: Rational Development of Self-Emulsifying Formulations for Improving The Oral Bioavailability of Poorly Soluble, Lipophilic Drugs
  • Design and Development of Supersaturatable Sedds (S-Sedds) Formulations for Enhancing The Gastrointestinal Absorption of Poorly Soluble Drugs