Inflammatory Bowel Disease - Debate Over Early Aggressive Treatment Continues

Summary

Introduction

Inflammatory bowel disease (IBD) is a chronic inflammatory condition that affects the gastrointestinal tract causing a number of distressing symptoms such as bleeding, diarrhea and abdominal pain. IBD includes key subsets Crohn's disease and ulcerative colitis, both of which can significantly impact on the quality of life of an individual.

Scope

• Analysis of the inflammatory bowel disease market based on a survey of 180 gastroenterologists supported by key opinion leader interviews
• Overview of epidemiology and patient segmentation in IBD
• Influences on gastroenterologists' prescribing behavior and their perception of current brands such as Remicade, Humira, Pentasa, Asacol and Lialda
• Assessment of outcomes of treatment with Remicade focusing on treatment failure and reasons for failure

Highlights

Clinical guidelines recommend a step-up treatment approach. However, Datamonitor's survey suggests that currently 20% of patients with severe IBD currently receive an early aggressive treatment approach. There is an ongoing debate among Gastroenterologists and Datamonitor believe this approach will become more commonplace in the future.

Remicade remains the first choice biologic therapy in 80% of biologic-nave patients. However, Humira has distinct advantages over Remicade that will lead to strong. Humira is positioned as a treatment for Remicade-failure patients, but Datamonitor's survey suggests currently only 30% of these patients go on to receive Humira.

Shire's Lialda (mesalazine), recently launched as a once-daily drug, is perceived by gastroenterologists to perform well on patient compliance. In a drug class where there is little differentiation between brands over efficacy and safety, Lialda will provide a clinical advantage thanks to its improved dosing regimen.

Reasons to Purchase

• Target prescribers more effectively, through an understanding of prescribing behavior and influencing factors
• Validate new product forecasting based on diagnosis and treatment rates, and the likely rate of uptake for new products
• Benchmark brand awareness and perceptions surrounding product positioning in order to formulate competitive lifecycle management strategies

Content