Islet Transplantation and Beta, Cell Replacement therapy

Summary

By 2010, the number of patients with diabetes is expected to reach expansive proportions. Outlining the most recent advances and research breakthroughs, this guide will demonstrate the impact of islet cell transplantation on treatment for insulin dependent diabetics within the next decade. Edited by a surgeon and endocrinologist at the forefront of the technology, this source considers challenges associated with this procedure, including the lack of sufficient donor organs and the side effects of immunosuppressive therapy.

Contents

• Brief History of Islet Transplantation
• Hypoglycaemia in Type 1 Diabetes: The Need for A New Approach
• Current Outcomes of Clinical Islet Transplantation
• Patient Selection and Assessment: An Endocrinologist's Perspective
• Surgical Aspects of Pancreas Procurement
• Aspects and Challenges of Islet Isolation
• Product Release Criteria and in Vitro Assays of Islet Function
• Radiological Aspects of Islet Function
• Surgical Aspects of Islet Implantation
• Care of The Islet Transplant Recipient: Immunosuppresive Management and Complications
• Metabolic Monitoring of The Islet Transplant Recipient
• Challenges in Setting-up A New Islet Transplant Program
• Key Factors to Consider in Setting-up Clinical Trails in Islet Transplantation from A Nursing Coordinator's Perspective
• Evolution of Single Donor Islet Transplant Protocols
• Culture and Transportation of Islets between Centres
• New Developments in Immunosuppression for Islet Transplantation
• Tolerance Protocols and Immunomodulation Is Islet Transplantation
• Xenotransplantation of Pancreatic Islets
• Approaches to B-Cell Regeneration and Neogenesis
• Stem Cell Approaches for Beta Cell Replacement
• Gene Therapy for Type 1 Diabetes