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Innovations in CNS
Novel therapeutics and future R&D strategies
Publication Date January 2007
Publisher Business Insights
Product Type Report
Pages 224
ISBN Number not applicable
Product Code RBI133
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Summary
The CNS drug market presents significant profit opportunities, but also carries high risks for companies aiming to achieve blockbuster status. Pipelines based on novel molecular targets to treat underlying disease promise to transform the treatment of psychiatric and neurological diseases, however research and development of these drugs requires an innovative approach to ensure investment is maximized.
Innovations in CNS: Novel therapeutics and future R&D strategies assesses novel treatments in development for major CNS disorders, comparing them with existing medications in terms of unmet need and forecasting their success in the commercial market. This report will enable you to understand the research tactics of your competitors and develop winning strategies for future growth in the lucrative CNS market. The report provides a survey of the pipelines of all of the major players in the CNS area. Detailed company profiles featured in the report include: AstraZeneca, GlaxoSmithKline, Merck & Co, Pfizer, and Sanofi-Aventis.
Use this report to understand the factors that will ensure your product pipeline achieves clinical and commercial success and analyze the product pipelines of the leading companies in the CNS market.
Key findings of the report...
- CNS pipelines show an unprecedented level of novelty against the industry trend of fewer new mechanisms making it to the market.
- Early signs of the long awaited impact of molecular biological technology in the CNS area are positive, with antibodies for Alzheimer's disease beginning to make real progress.
- Companies are moving away from merely treating symptoms to looking for interventions that treat the underlying disease state for conditions such as Alzheimer's and Parkinson's diseases.
- In spite of some early failures companies are still investing enormous resources in bringing NK-1 (Substance P) antagonists through clinical development.
- The success of antagonists for NK-2 or NK-3 receptors for the treatment of psychoses is likely to open up intense activity in that area as companies strive to catch up with the current leaders.
- Company size does not relate to level of novelty in pipelines. Large companies vary hugely in the level of innovation in their pipelines and small companies can compete in the blockbuster arena with innovative molecules.
Key questions answered in this report
- What indications will see an increase in innovative launches in the next few years?
- Which companies will become key players in the CNS market?
- What roles will big pharma and SME/biotech companies play in the future of CNS treatment?
- Is molecular biology only an enabling technology in CNS drug discovery?
- What does the future of hold for CNS blockbuster drugs?
- Which pipeline products feature highest growth potential and why?
- What are the key unmet needs within the major sub-indications of depression, anxiety, schizophrenia, sleep disorders, Alzheimer's, movement disorders and pain?
Top five reasons to order your copy today
- Analyze patient potential, economic burden and key unmet needs in 10 major CNS disorders across the US, EU and Japan, including schizophrenia, depression and Alzheimer's disease.
- Understand how key preclinical and clinical trials are impacting CNS drug development, enabling you to assess new innovations and anticipate future trends in the market.
- Assess your organisation's position in the market-place, and develop innovative future strategies to ensure you are positioned for success.
- Discover novel treatment strategies for all major therapeutic areas in psychaitry and neurology.
- Gain access to the CNS pipelines of leading companies including Sanofi-Aventis, Pfizer and AstraZeneca to understand their differing portfolio management strategies.
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Content
- Executive Summary
- Current market landscape & dynamics
- Major depressive disorder
- Anxiety disorders
- Schizophrenia
- Sleep disorders
- Alzheimer's disease and other dementias
- Movement disorders
- Epilepsy
- Pain
- Pipeline analysis: paradigm shift and incremental innovation
- Chapter 1 Current market landscape & dynamics
- Summary
- Introduction
- Patient potential
- The current CNS market
- CNS sales by disease and top 5 brands per disease category
- CNS sales by drug class
- CNS sales by country
- Top CNS companies
- Top CNS brands
- Unmet needs
- Psychiatric disorders
- Depression
- Anxiety
- Schizophrenia
- Sleep disorders
- Neurologic disorders
- Alzheimer's
- Epilepsy
- Movement disorders
- Pain
- Innovations in CNS
- Chapter 2 Major depressive disorder
- Summary
- Introduction
- Epidemiology and economic burden
- Current drug treatments
- Limitations
- Key unmet needs
- Novel treatments for major depressive disorder
- Directly acting serotonergic receptor agonists
- Specific noradrenaline reuptake inhibitors (NARI)
- Serotonin/noradrenaline reuptake inhibitors (SSNRI) and mixed, multiple reuptake inhibitors (MMRI)
- Multi-target strategies
- Neuropeptides and stress
- Neurokinins
- CRF-1
- Others
- Future directions
- Conclusions
- Chapter 3 Anxiety disorders
- Summary
- Introduction
- Epidemiology and economic burden
- Current drug treatments
- Limitations
- Key unmet needs
- Novel treatments for anxiety disorders
- GABA-A positive modulators
- 5-HT1A receptor agonists
- ?-3-adrenoceptor agonists
- NK-1 and CRF-1 receptor antagonists
- AVP V1b antagonists
- v Cholecystokinin-2 (CCK-2) receptor antagonists
- Fatty acid amide hydrolase (FAAH) inhibitors
- Metabotropic glutamate 3 (mGlu3) receptor agonists and mGlu5 receptor antagonists
- Vomeropherins
- Future directions
- Conclusions
- Chapter 4 Schizophrenia
- Summary
- Introduction
- Epidemiology and economic burden
- Current drug treatments
- Limitations
- Key unmet needs
- Novel treatments for schizophrenia
- Monoaminergic systems
- Dopamine
- 5-HT2A receptor antagonists and inverse agonists
- Combined monoamine receptor antagonists
- D2/5-HT2A
- D2/5-HT1A
- Non-monoaminergic strategies
- Glutamate
- Cholinergics
- Neuropeptides
- Future directions
- Conclusions
- Chapter 5 Sleep disorders
- Summary
- Introduction
- Epidemiology and economic burden
- Current drug treatments
- Limitations
- Key unmet needs
- Novel treatments for sleep disorders
- GABA-ergic treatments
- Serotonergic treatments
- vi Others
- Future directions
- Conclusions
- Chapter 6 Alzheimer's disease & other dementias
- Summary
- Introduction
- Epidemiology and economic burden
- Current drug treatments
- Acetylcholinesterase inhibitors
- NMDA antagonists
- Limitations
- Key unmet needs
- Novel treatments for Alzheimer's disease
- Symptomatic treatments
- Cholinergic mechanisms
- Glutamatergic mechanisms
- Serotonergic mechanisms
- Other mechanisms
- Disease process modifiers
- Amyloid cascade based treatments
- Neuroinflammatory approaches
- Neurotrophic factor approaches
- Future directions
- Conclusions
- Chapter 7 Movement disorders
- Summary
- Introduction
- Parkinson's disease
- Epidemiology and economic burden
- Current drug treatments
- Limitations
- Key unmet needs
- Novel treatments for Parkinson's disease
- Adenosine A2A receptor antagonists
- Stem cell and gene therapy for the dopaminergic system
- Disease modifying strategies for PD
- vii Glutamatergic strategies
- Motor neuron disease/amyolateral sclerosis
- Epidemiology and economic burden
- Current drug treatments
- Novel treatments for motor neuron disease/amyolateral sclerosis
- Drug discovery approaches
- Future directions
- Huntington's disease
- Epidemiology and economic burden
- Current drug treatments
- Novel treatments for Huntington's disease
- Future directions
- Conclusions
- Chapter 8 Epilepsy
- Summary
- Introduction
- Epidemiology and economic burden
- Current drug treatments
- Limitations
- Key unmet needs
- Novel treatments for epilepsy
- GABA-ergic treatments
- Ion channels
- Glutamate
- NMDA antagonists
- AMPA antagonists
- NS1209
- E2007
- Talampanel/LY300164
- Junction gap blockers
- Future directions
- Conclusions
- Chapter 9 Pain
- Summary
- Introduction
- Epidemiology and economic burden
- Current drug treatments
- viii Limitations
- Key unmet needs
- Novel treatments for pain disorders
- Pain
- NMDA receptor antagonists
- Cannabinoids
- Calcium channel modulators
- Nicotinic receptor agonists
- Mu opiate receptor agonists
- Delta opiates
- Migraine
- Triptans and NSAIDs
- Non-serotonergic treatments
- Calcitonin Gene Related Peptide (CGRP)
- Gap junction blockers
- Vanilloids
- Ion channel blockers
- Other novel mechanisms
- Conclusions
- Chapter 10 Pipeline analysis: paradigm shift and incremental innovation
- Summary
- Introduction
- Risk and innovation: not a straight choice
- Sanofi-Aventis
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Merck & Co.
- Building on the value of the pipeline
- Conclusions
- Limited impact of the genomics revolution
- The problem of diagnosis
- Away from the blockbuster model: smaller markets, smaller indications, and the place of smaller companies
- Chapter 11 Appendix
- List of Figures
- Figure 1.1: Evaluation of current treatment options for CNS indications
- Figure 2.2: Competitive dynamics of drug classes and leading brands in the depression market, 2005
- Figure 4.3: Competitive dynamics of drug classes and leading brands in the schizophrenia market, 2005
- Figure 6.4: Competitive dynamics of drug classes and leading brands in the Alzheimer's disease market, 2005
- Figure 7.5: Competitive dynamics of leading brands in the Parkinson's disease market, 2005
- Figure 8.6: Competitive dynamics of drug classes and leading brands in the epilepsy market, 2005
- List of Tables
- Table 1.1: Prevalence of CNS disorders in the 7 major markets (US, Japan, France, Germany, Italy, Spain, UK), 2005
- Table 1.2: Global CNS market dales by disease category, 2004-05
- Table 1.3: Top 5 brands in each disease category, 2005
- Table 1.4: Global CNS market sales by drug class, 2004-05
- Table 1.5: CNS drug sales by country, 2005
- Table 1.6: Top 20 companies in the CNS market by sales, 2005
- Table 1.7: Top 20 global CNS brands, 2005
- Table 1.8: Medicinal chemical properties of a successful CNS drug
- Table 2.9: Present development status of potential antidepressants, 2006
- Table 3.10: Present development status of potential anxiolytics Phase II and III, 2006
- Table 3.11: Present development status of potential anxiolytics Phase I and Preclinical, 2006
- Table 4.12: Present development status of potential antipsychotics, 2006
- Table 5.13: Drugs currently in use for the treatment of insomnia, 2006
- Table 5.14: Present development status of potential hypnotics, 2006
- Table 6.15: Present development status of potential symptomatic treatments for Alzheimer's disease, 2006
- Table 6.16: Present development status of potential disease modifying treatments for Alzheimer's disease, 2006
- Table 7.17: Present development status of potential treatments for Parkinson's disease, 2006
- Table 7.18: Present development status of potential treatments for motor neuron disease/ALS, 2006
- Table 7.19: Present development status of potential treatments for Huntington's disease, 2006
- Table 8.20: Present development status of potential novel anti-epileptic drugs, 2006
- Table 9.21: Side effects limiting the pharmacological treatment of pain with present pharmaceuticals
- Table 9.22: Present development status of potential treatments for pain disorders, 2006
- Table 9.23: Present development status of potential treatments for migraine disorders, 2006
- Table 10.24: Sanofi-Aventis' CNS pipeline, 2006
- Table 10.25: Pfizer's CNS pipeline, 2006
- Table 10.26: AstraZeneca's CNS pipeline, 2006
- Table 10.27: GlaxoSmithKline CNS pipeline, 2006
- Table 10.28: Merck & Co.'s CNS pipeline, 2006
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