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Hereditary Breast Cancer


Publication Date   September 2007
Publisher   Informa Healthcare
Product Type   Book
Pages   352
ISBN Number   978-0-8493-9022-7
Product Code   IFH105
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Price £105.00

approximately: $156 | €124

Summary


Practically focusing on the needs of the medical oncologist, obstetrician, and gynecologist, this source analyzes the epidemiological, biological, and clinical issues associated with hereditary breast cancer, and offers clear guidance on the application and utilization of cancer risk assessment models, screening options for individuals with HBS, and the identification of high-risk patients. Addressing every essential aspect of HBC, this source offers succinct analyses of HBC-associated syndromes, low penetrance genes, and mutations of the BRCA 1 and BRCA 2 genes.

Content


  • Overview of Hereditary Breast Cancer
    • Genetic Epidemiology of Hereditary Breast Cancer
    • Risk Estimation Models
  • Hbc Syndromes with Known Genetic Etiologies
    • Cowden's Syndrome
    • Li-Fraumeni Syndrome
    • Other Syndromes That Include Breast Cancer as A Component
    • Low Penetrance Genes
  • Assessment and Dissemination of Clinical Risks for Brca1/2 Mutation Carriers
    • Biology of Brca1/2-Associated Carcinogenesis
    • Use of Risk Estimation Models in Clinical Practice
    • Genetic Testing and Counseling Issues
    • Mutation Screening Methods and Limitations
    • Risk Modifiers
    • Brca1/2 in Underserved or Special Populations
    • Psychological Impact of Testing
  • Screening and Prevention of Hbc in Brca1/2 Mutation Carriers
    • Breast Cancer Screening in High Risk Individuals
    • Ovarian Cancer Screening in High Risk Individuals
    • Surgical Prevention of Breast and Ovarian Cancer
    • Chemoprevention of Breast and Ovarian Cancer
    • Lifestyle Modification and Other Prevention Approaches
    • Management of Mutation-Negative Women
    • Synthesis of Screening and Prevention Options
  • Cancer Management and Outcomes in Brca1/2 Mutation Carriers
    • Pathology in Mutation Carriers
    • Local Treatment Issues in Hbc
    • Systemic Treatment Issues
    • Cancer Management Issues in Brca1/2 Tested Negative Women