Cancer Vaccines Drug

Summary

Cancer vaccines offer an attractive therapeutic addition, delivering treatment of high specificity, low toxicity and prolonged activity. However, despite years of R&D, a reproducible survival benefit has proved elusive, leaving the market wide open.
There are today 195 (165) companies plus partners developing 218 (194) cancer vaccine drugs in 360 (284) developmental projects in cancer. In addition, the accumulated number of ceased drugs over the last years amount to another 175 (149) drugs. Cancer Vaccines Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 97 (84) different targets. These targets are further categorized on the CD-ROM by 38 (38) classifications of molecular function and with pathway referrals to BioCarta, KEGG and NetPath. Figures in brackets are comparative data from last year.

Find and sort drugs by twelve different parameters plus free text search field. Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser, whether it is a single drug profile or an entire search you want have a report of.

How May Drug Pipeline Update Be of Use?

• Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
• Find competitors, collaborations partners, M&A candidates etc.
• Jump start competitive drug intelligence operations
• Excellent starting point for world wide benchmarking
• Compare portfolio and therapy focus with your peers
• Speed up pro-active in-/out licensing strategy work
• Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
• Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators

Includes more than 195 (165) principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.

Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms

Lists commercial, generic and code names for drugs.

Developmental stage

This Drug Pipeline Update contains 218 (194) cancer vaccine drugs in active development, which have a total of 360 (284) developmental projects in cancer:
Marketed 8 (7)
Registered 2
Pre-registration 2 (1)
Phase III 18 (14)
Phase II 97 (71)
Phase I 76 (75)
Preclinical 123 (103)
No Data 18 (18)
Suspended 10
Discontinued 7

In addition there are 175 (149) ceased drugs.

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

Included cancer vaccine drugs are also in development for 70 (64) other indications, where of 45 (41) are different cancer indications.

Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

Identified drugs are linked to more than 97 (84) different targets, divided into 38 (38) classifications of molecular function:

• Acid phosphatase activity
• Carboxypeptidase activity
• Catalytic activity
• Cell adhesion molecule activity
• Chaperone activity
• Cofactor binding
• Complement activity
• Cytokine activity
• DNA binding
• DNA topoisomerase activity
• DNA-directed DNA polymerase activity
• Growth factor activity
• Heat shock protein activity
• Hormone activity
• Hydrolase activity
• Isomerase activity
• Kinase binding
• Kinase regulator activity
• Metallopeptidase activity
• MHC class I receptor activity
• Molecular function unknown
• Oxidoreductase activity
• Peptidase activity
• Peptide hormone
• Protein binding
• Protein serine/threonine kinase activity
• Protein-tyrosine kinase activity
• Receptor activity
• Receptor signaling complex scaffold activity
• Receptor signaling protein serine/threonine kinase activity
• RNA-directed DNA polymerase activity
• Serine-type peptidase activity
• T cell receptor activity
• Transcription factor activity
• Transcription regulator activity
• Transmembrane receptor activity
• Transmembrane receptor protein tyrosine kinase activity
• Transporter activity

Identified targets are categorized into 20 (20) different primary and alternate sub-cellular localizations:

• Apical membrane
• Centrosome
• Clathrin-coated vesicle
• Cytoplasm
• Cytoskeleton
• Endoplasmic reticulum
• Endosome
• Extracellular
• Extracellular matrix
• Golgi apparatus
• Integral to membrane
• Lysosome
• Mitochondrial matrix
• Mitochondrion
• Nucleolus
• Nucleus
• Peroxisomal matrix
• Plasma membrane
• Sarcoplasmic reticulum
• Secreted
• Secretory granule

Note: You are able to find and sort drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile

Direct links are provided from inside the application to 99 (81) protein expression profiles of 66 (55) drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

• 48 different normal tissue types
• 20 different types of cancer
• 47 cell lines
• 12 samples of primary blood cells

Pathway Referals

Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG and NetPath.

• BioCarta 108 (103) Pathways
• KEGG 85 (64) Pathways
• NetPath 16 (16) Signaling Pathways

Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

In total there are 72 (63) different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms

Presentation of drug name and synonyms

Principal Investigator & Partners

Presentation of principal investigator and partners

Target and Molecular Function of Target

Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization

Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles

Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

48 different normal tissue types

20 different types of cancer

47 cell lines

12 samples of primary blood cells

Targeted Pathways

Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

Mechanism

Drug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.

Example:

Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

Short introduction to drug

Compound Data

Compound type, Chemical name, CAS Number and molecular weight

Patent Data

Available patent information related to the drug is presented here.

Business & Markets

Collaborations and deals

Approvals and submissions

Analyst comments

Phase III Data

Available Phase III development data, developmental history and scientific data.

Phase II Data

Available Phase II development data, developmental history and scientific data.

Phase I Data

Available Phase I development data, developmental history and scientific data.

Preclinical Data

Available preclinical development data, developmental history and scientific data.

Licensing Information

Availability for licensing

Application Features

Use 13 different parameters, available in drop-down menus, to find and sort among drugs

• Drug status
• Clinical Trial Status
• Principle Investigator
• Partners
• Indication
• Developmental Stage
• Compound Type
• Mechanism
• Target
• Molecular Function of Target
• Target Localization
• Targeted Pathways
• Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources

• Drug data is linked to search engines like Google and PubMed
• Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
• Direct links to company web pages of principal investigators

Dynamic Report Generator

Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

• AMD-Athlon/Pentium II PC
• Windows 98/NT4/2000/ME/XP/VISTA/Windows 7
• 8x-speed CD Rom drive
• SVGA 16 bit display. (32 bit recommended)
• 32 MB of available RAM (128 MB recommended)
• Browser Application (Internet Explorer, Firefox)
• Internet access (to access related internet resources)

Contents

Please Note: Due to the Nature of This Report The Number of Pages and Toc is Not Available