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Cancer Vaccines: Aim and Shoot


Publication Date   May 2008
Publisher   Bioseeker
Product Type  
Pages   184
ISBN Number   not applicable
Product Code   BSK174
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Price £1,535.00

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Summary


This report aims to analyze the current and future potential of cancer vaccines by examining key fundamentals across the entire pipeline of cancer vaccine drug candidates. BioSeeker has identified three fundamental dimensions to outline the competitive landscape within the pharmaceutical industry; compound type, therapy area and target type. For the purposes of this report, BioSeeker is focusing on therapeutic cancer vaccines and as such the commercialized and pipeline prophylactic agents have not been included.

This report is written for you to identify your competition and understand which targeting strategies are at work within cancer vaccine drug development. It allows you to pin-point which competitors drugs' clinical out-come may have bearing on your own drug development and who are developing sequels to blockbuster drugs. This report also helps you to locate white-spots in the competitive landscape, giving you little or no competition. Conversly it may reveal unexpected competition for you.

Drug targets are the critical link between drugs and their role in the treatment of medical disorders. BioSeeker has surveyed cancer vaccines and identified 75 drug targets belonging to 109 drugs. This report, Cancer Vaccine: Aim and Shoot, is an open landscape of resources to build, fuel, and drive your scientific competitive vehicle for the advancement of cancer vaccine drugs.

In the report, BioSeeker reports on 66 unique drug target combinations, each comprised of a different collection or mix of individually defined targets, for 109 cancer vaccine drugs designed for the treatment of 37 different cancer indications. The highest degree of distinctiveness among cancer vaccine drugs is achieved by sorting each of them according to targeted cancer indication, drug target mix, and drug compound type. At the same time we are also identifying peer groups of drugs, that is, drugs we consider suitable for head-to-head comparison during drug development.

To fuel the scientific and competitive thinking, BioSeeker opens the gate into the presence and relevance of protein-protein interactions between identified targets of cancer vaccine drugs. No less than 64 protein-protein interactions were recognized among and between 41 of the 75 included cancer vaccine drug targets.

Why You Should Own Your Own Copy of this Report:

  • 180+ pages, with almost a hundred different tables and figures. Includes more than 1,000 active links to related resources on the Internet
  • A 109 cancer vaccine drugs analysis, under development by 76 investigators, covering more than 236 developmental projects in cancer
  • 75 unique, in-depth, drug target profiles, highlighting twelve themes about the drug target, i.e. protein-protein interaction with other drug targets, pursued cancer indications, drugs under development, compound types, presence in the Cancer Genome Project etc.
  • A unique drug target combination breakdown of cancer vaccines into tumor type, compound type, and developmental stage
  • Unique drug-protein target and protein-protein of drug targets interactome analysis
  • Pathway profiling of cancer vaccine drug targets
  • Pin-point which competitor drugs' clinical out-come may have bearing on your own drug development
  • Who are working on sequels to blockbuster drugs?
  • Locate white-spots in the competitive landscape, giving you little or no competition

In all, this report is a serious reference for any professional interested in the development of oncology drug targets and the selection/validation of targeting strategies.

Content


  • 1 Executive Summary
  • 2 About Cancer Highlights
  • 3 Methodologies
  • 4 Table of Contents
    • 4.1 List of Figures
    • 4.2 List of Tables
  • 5 How to Use this Report
  • 6 Cancer Vaccines Types
  • 7 The Cancer Genome Project and Cancer Vaccine Drug Targets
    • 7.1 Cancer Vaccine Drug Targets Present in the Cancer Gene Census and in the Catalogue of
      • Somatic Mutations in Cancer
  • 8 Protein Expression Profiles of Cancer Vaccine Drug Targets in Human
    • 8.1 Expression in Normal Tissues and Cancer Tissues
    • 8.2 Expression in Human Cancer Cell Lines and Primary Cells
  • 9 Pathway Analysis of Cancer Vaccine Drugs
  • 10 Protein-Protein Interactions Among Identified Cancer Vaccine Drug Targets
  • 11 Available Biological Structure Data on Cancer Vaccine Drug Targets
  • 12 Drug Target Profiles of Cancer Vaccine Drug Targets in Oncology
      • 12.1.1 Acid phosphatase activity
      • 12.1.2 Carboxypeptidase activity
      • 12.1.3 Catalytic activity
      • 12.1.4 Cell adhesion molecule activity
      • 12.1.5 Chaperone activity
      • 12.1.6 Cofactor binding
      • 12.1.7 Complement activity
      • 12.1.8 Cytokine activity
      • 12.1.9 DNA binding
  • 4 Cancer Vaccines: Aim and Shoot
  • 10 Cancer Highlights No 1 Vol 8 2008| BioSeeker Group AB c 2008
      • 12.1.10 DNA topoisomerase activity
      • 12.1.11 DNA-directed DNA polymerase activity
      • 12.1.12 Growth factor activity
      • 12.1.13 Hormone activity
      • 12.1.14 Hydrolase activity
      • 12.1.15 Intracellular ligand-gated ion channel activity
      • 12.1.16 Kinase binding
      • 12.1.17 Kinase regulator activity
      • 12.1.18 Metallopeptidase activity
      • 12.1.19 MHC class I receptor activity
      • 12.1.20 Molecular function unknown
      • 12.1.21 Oxidoreductase activity
      • 12.1.22 Peptidase activity
      • 12.1.23 Peptide hormone
      • 12.1.24 Protein binding
      • 12.1.25 Protein serine/threonine kinase activity
      • 12.1.26 Protein-tyrosine kinase activity
      • 12.1.27 Receptor activity
      • 12.1.28 Receptor binding
      • 12.1.29 Receptor signaling complex scaffold activity
      • 12.1.30 RNA-directed DNA polymerase activity
      • 12.1.31 Serine-type peptidase activity
      • 12.1.32 T cell receptor activity
      • 12.1.33 Transcription factor activity
      • 12.1.34 Transmembrane receptor activity
      • 12.1.35 Transmembrane receptor protein tyrosine kinase activity
      • 12.1.36 Transporter activity
      • 12.1.37 Viral Protein
  • 13 The Drug-Protein Interactome of Cancer Vaccines
  • 14 The Progression and Maturity of Cancer Vaccine Drug Target Combinations
    • 14.1 Target Profiles of Cancer Vaccines in Pre-Registration or on the Market
    • 14.2 New Cancer Vaccine Target Combinations in Phase III Clinical Development
    • 14.3 New Cancer Vaccine Target Combinations in Phase II Clinical Development
    • 14.4 New Cancer Vaccine Target Combinations Phase I Clinical Development
    • 14.5 New Cancer Vaccine Target Combinations in Preclinical Development
    • 14.6 Development Profiles of All Identified Cancer VaccineTarget Combinations
  • 15 Cancer Vaccine Drug Target Mix by Cancer Indication
    • 15.1 Anal Dysplasia
    • 15.2 Basal Cell Cancer
    • 15.3 Bladder Cancer
    • 15.4 Bone Cancer
    • 15.5 Brain Cancer
    • 15.6 Breast Cancer
    • 15.7 Cervical Cancer
    • 15.8 Cervical Dysplasia
    • 15.9 Chemotherapy-Induced Bone Marrow Injury
      • 15.9.1 Chemotherapy-Induced Neutropenia
    • 15.10 Colorectal Cancer
    • 15.11 Gastrointestinal Cancer
    • 15.12 Head and Neck Cancer
    • 15.13 Leukemia
      • 15.13.1 Acute Myelogenous Leukemia
      • 15.13.2 Chronic Lymphocytic Leukemia
      • 15.13.3 Chronic Myelogenous Leukemia
    • 15.14 Liver Cancer
    • 15.15 Lung Cancer
      • 15.15.1 Non-Small Cell Lung Cancer
      • 15.15.2 Small Cell Lung Cancer
    • 15.16 Lymphoma
      • 15.16.1 B-Cell Lymphoma
      • 15.16.2 Non-Hodgkins Lymphoma
      • 15.16.3 T-Cell Lymphoma
    • 15.17 Myelodysplastic Syndrome
  • 4 Cancer Vaccines: Aim and Shoot
  • 12 Cancer Highlights No 1 Vol 8 2008| BioSeeker Group AB c 2008
    • 15.18 Myeloma
    • 15.19 Nasopharyngeal Cancer
    • 15.20 Oesophageal Cancer
    • 15.21 Ovarian Cancer
    • 15.22 Pancreatic Cancer
    • 15.23 Prostate Cancer
    • 15.24 Renal Cancer
    • 15.25 Sarcoma
    • 15.26 Skin Cancer
      • 15.26.1 Melanoma
    • 15.27 Thyroid Cancer
  • 16 Cancer Vaccine Drugs and Their Targets by Companies
    • 16.1 Australia
    • 16.2 Canada
    • 16.3 China
    • 16.4 Denmark
    • 16.5 France
    • 16.6 Germany
    • 16.7 India
    • 16.8 Israel
    • 16.9 Italy
    • 16.10 Japan
    • 16.11 Netherlands
    • 16.12 Norway
    • 16.13 South Korea
    • 16.14 Switzerland
    • 16.15 United Kingdom
    • 16.16 USA
    • 16.17 Non-Industrial Bodies
  • 17 Disclaimer
  • 18 Drug Index
  • 19 Company Index
  • 4.1 List of Figures
    • Figure 1: Distribution of Compound Types Among Cancer Vaccines19
    • Figure 2: Primary Sub-cellular Localization of Drug Targets20
    • Figure 3: Visualization of Protein-Protein Interactions Among Cancer Vaccine Drug Targets
    • Figure 4: The Vaccine-Protein Interactome of Cancer Vaccines
    • Figure 5: Direct Head-to-Head Targeting Interactome of Cancer Vaccines
  • 4.2 List of Tables
    • Table 2: Drug Targets of Cancer Vaccines Present in the Catalogue of Somatic Mutations in Cancer and in the Cancer Gene Census
    • Table 3: Available Protein Expression Profiles of Cancer Vaccine Drug Targets
    • Table 4: Pathway Summary
    • Table 5: Drug Targets Without any Identified Assigned Pathways
    • Table 6: Pathway Profile According to BioCarta of Cancer Vaccine Targets
    • Table 7: Pathway Profile According to KEGG of Cancer Vaccine Targets
    • Table 8: Cancer Vaccines Targeting Major Singaling Pathways41
    • Table 9: Protein-Protein Interactions Among Cancer Vaccine Drug Targets
    • Table 10: Number of Available Biological Structures on Cancer Vaccine Targets
    • Table 11: Overview of Drug Target Profile Themes48
    • Table 12: Vaccine-Protein Target Clusters in the Cancer Vaccine Drug Target Interactome
    • Table 13: Fall Out in Terms of the Total Number of Drug Target Mixes, Drugs, Developmental Projects, and the Presence of New Drug Target Mixes by Developmental Stage128
    • Table 14: Target Profiles of Cancer Vaccines in Pre-Registration or on the Market128
    • Table 15: New Cancer Vaccine Drug Target Combinations in Phase III Clinical Development
    • Table 16: New Cancer Vaccine Target Combinations in Phase II Clinical Development
    • Table 17 New Cancer Vaccine Target Combinations Phase I Clinical Development
    • Table 18: New Cancer Vaccine Target Combinations in Preclinical Development
    • Table 19: Top 5 Pursued Cancer Vaccine Targets
    • Table 20: The Progression, Maturity and Comptitive Comparison of Cancer Vaccine Target Mixes in Development
    • Table 21: Number of Cancer Vaccine Drug Target Mixes Reported by Cancer Indication
    • Table 22: Locating Your Competitors/Peers V Step 1
    • Table 23: Locating Your Competitors/Peers V Step 2
    • Table 24: Drug Targets of Cancer Vaccines for the Treatment of Anal Dysplasia According to the Compound Type and Developmental Stage of Vaccine
    • Table 25: Drug Targets of Cancer Vaccines for the Treatment of Basal Cell Cancer According to the Compound Type and Developmental Stage of Vaccine143
    • Table 26: Drug Targets of Cancer Vaccines for the Treatment of Bladder Cancer According to the Compound Type and Developmental Stage of Vaccine143
    • Table 27: Drug Targets of Cancer Vaccines for the Treatment of Bone Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 28: Drug Targets of Cancer Vaccines for the Treatment of Brain Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 29: Drug Targets of Cancer Vaccines for the Treatment of Breast Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 30: Drug Targets of Cancer Vaccines for the Treatment of Cervical Cancer According to the Compound Type and Developmental Stage of Vaccine147
    • Table 31: Drug Targets of Cancer Vaccines for the Treatment of Cervical Dysplasia According to the Compound Type and Developmental Stage of Vaccine148
    • Table 32: Drug Targets of Cancer Vaccines for the Treatment of Chemotherapy-Induced Bone Marrow Injury (General) According to the Compound Type and Developmental Stage of Vaccine
    • Table 33: Drug Targets of Cancer Vaccines for the Treatment of Chemotherapy-Induced Neutropenia According to the Compound Type and Developmental Stage of Vaccine
    • Table 34: Drug Targets of Cancer Vaccines for the Treatment of Colorectal Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 35: Drug Targets of Cancer Vaccines for the Treatment of Gastrointestinal Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 36: Drug Targets of Cancer Vaccines for the Treatment of Head and Neck Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 37: Drug Targets of Cancer Vaccines for the Treatment of Leukemia (General) According to the Compound Type and Developmental Stage of Vaccine
    • Table 38: Drug Targets of Cancer Vaccines for the Treatment of Acute Myelogenous Leukemia According to the Compound Type and Developmental Stage of Vaccine152
    • Table 39: Drug Targets of Cancer Vaccines for the Treatment of Chronic Lymphocytic Leukemia According to the Compound Type and Developmental Stage of Vaccine
    • Table 40: Drug Targets of Cancer Vaccines for the Treatment of Chronic Myelogenous Leukemia According to the Compound Type and Developmental Stage of Vaccine
    • Table 41: Drug Targets of Cancer Vaccines for the Treatment of Liver Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 42: Drug Targets of Cancer Vaccines for the Treatment of Lung Cancer (General) According to the Compound Type and Developmental Stage of Vaccine
    • Table 43: Drug Targets of Cancer Vaccines for the Treatment of Non Small Cell Lung Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 44 Drug Targets of Cancer Vaccines for the Treatment of Small Cell Lung According to the Compound Type and Developmental Stage of Vaccine
    • Table 45: Drug Targets of Cancer Vaccines for the Treatment of Lymphoma (General) According to the Compound Type and Developmental Stage of Vaccine
    • Table 46: Drug Targets of Cancer Vaccines for the Treatment of B-Cell Lymphoma According to the Compound Type and Developmental Stage of Vaccine
    • Table 47: Drug Targets of Cancer Vaccines for the Treatment of non-Hodgkins Lymphoma According to the Compound Type and Developmental Stage of Vaccine
    • Table 48: Drug Targets of Cancer Vaccines for the Treatment of T-Cell Lymphoma According to the Compound Type and Developmental Stage of Vaccine
    • Table 49: Drug Targets of Cancer Vaccines for the Treatment of Myelodysplastic Syndrome According to the Compound Type and Developmental Stage of Vaccine
    • Table 50: Drug Targets of Cancer Vaccines for the Treatment of Myeloma According to the Compound Type and Developmental Stage of Vaccine
    • Table 51: Drug Targets of Cancer Vaccines for the Treatment of Nasopharyngeal Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 52: Drug Targets of Cancer Vaccines for the Treatment of Oesophageal Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 53: Drug Targets of Cancer Vaccines for the Treatment of Ovarian Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 54: Drug Targets of Cancer Vaccines for the Treatment of Pancreatic Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 55: Drug Targets of Cancer Vaccines for the Treatment of Prostate Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 56: Drug Targets of Cancer Vaccines for the Treatment of Renal Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 57: Drug Targets of Cancer Vaccines for the Treatment of Sarcoma According to the Compound Type and Developmental Stage of Vaccine165
    • Table 58: Drug Targets of Cancer Vaccines for the Treatment of Skin Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 59: Drug Targets of Cancer Vaccines for the Treatment of Melanoma According to the Compound Type and Developmental Stage of Vaccine
    • Table 60: Drug Targets of Cancer Vaccines for the Treatment of Thyroid Cancer According to the Compound Type and Developmental Stage of Vaccine
    • Table 61: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Australia169
    • Table 62: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Canada169
    • Table 63: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in China
    • Table 64: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Denmark170
    • Table 65: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in France170
    • Table 66: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Germany171
    • Table 67: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in India171
    • Table 68: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Israel171
    • Table 69: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Italy
    • Table 70: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Japan
    • Table 71: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in the Netherlands
    • Table 72: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Norway173
    • Table 73: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in South Korea
    • Table 74: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in Switzerland173
    • Table 75: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in United Kingdom
    • Table 76: Cancer Vaccines with Drug Target Mix and Developmental Projects by Companies in USA174
    • Table 77: Cancer Vaccines with Drug Target Mix and Developmental Projects by Non-Industrial Bodies178