Summary
Executive Summary
Despite the heavy investment made into brain cancer research, primary brain cancer, with glioblastoma multiforme being the most aggressive and most common form, remains one of the most deadly diseases in the developed world. While primary brain tumors are relatively rare, the chances of survival for patients with the disease are very low, even with the best treatment options currently available.
Datamonitor predicts that there will be around 26,000 new cases of glioblastoma multiforme diagnosed in the seven major markets (US, Japan, France, Germany, Italy, Spain and UK) in 2007. In the US alone, around 14,000 people will die from brain cancer in 2007.
There are today more than 120 therapeutics targeting brain cancer, from early preclinical to marketed drugs. Brain Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 77 different targets. These targets are further categorized on the CD-ROM by 29 classifications of molecular function and their possible belonging to 17 different signaling pathways in the cell. Read more below on how the Brain Cancer Drug Pipeline Update is organized.
How May Drug Pipeline Update Be of Use?
- Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operations
- Excellent starting point for world wide benchmarking
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/out licensing strategy work
- Fast and easy way of tracking drugs using search engines; just one click and you may search the World Wide Web and PubMed for any drug.
- Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
Investigators Includes more than 100 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 240 names
Developmental stage This Drug Pipeline Update contains more than 120 drugs in active development for the treatment of brain cancer:
- 10 marketed drugs
- 9 drugs in Phase III
- 49 drugs in Phase II
- 23 drugs in Phase I
- 30 drugs in Preclinical
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications Included 120+ drugs are also in development for over 100 other indications.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
Targets Identified drugs are linked to 77 different targets, divided into 29classifications of molecular function:
- Auxiliary transport protein activity
- Catalytic activity
- Cell adhesion molecule activity
- Cysteine-type peptidase activity
- Cytokine activity
- DNA repair protein
- DNA topoisomerase activity
- DNA-directed DNA polymerase activity
- Extracellular ligand-gated ion channel activity
- G-protein coupled receptor activity
- Growth factor activity
- Kinase activity
- Ligand-dependent nuclear receptor activity
- Lipid kinase activity
- Lipid phosphatase activity
- Peptidase activity
- Protein serine/threonine kinase activity
- Protein-tyrosine kinase activity
- Receptor activity
- Receptor signaling protein serine/threonine kinase activity
- Receptor signaling protein tyrosine phosphatase activity
- Structural constituent of cytoskeleton
- T cell receptor activity
- Transcription factor activity
- Transcription regulator activity
- Transferase activity
- Translation regulator activity
- Transmembrane receptor activity
- Transmembrane receptor protein tyrosine kinase activity
Identified targets are categorized into 11 different primary and alternate localizations:
- Clathrin-coated vesicle
- Cytoplasm
- Cytosol
- Endoplasmic reticulum
- Endosome
- Extracellular
- Mitochondrion
- Nucleolus
- Nucleus
- Plasma membrane
- Secreted
Note: You are able to sort and find drugs according to target name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile Direct links are provided from inside the application to protein expression profiles of 35 drug targets in various human tissues, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Targeted Signaling Pathways Identified targets have been cross referenced against 20 signaling pathways, and no less than 17 are currently being pursued in brain cancer drug development:
- Alpha6 Beta4 Integrin Signaling Pathway
- Androgen Receptor Signaling Pathway
- B Cell Receptor Signaling Pathway
- EGFR1 Signaling Pathway
- IL-1 Signaling Pathway
- IL-2 Signaling Pathway
- IL-3 Signaling Pathway
- IL-4 Signaling Pathway
- IL-5 Signaling Pathway
- IL-6 Signaling Pathway
- IL-9 Signaling Pathway
- Kit Receptor Signaling Pathway
- Notch Signaling Pathway
- T Cell Receptor Signaling Pathway
- TGF-beta Receptor Signaling Pathway
- TNF-alpha Signaling Pathway
- Wnt Signaling Pathway
Note: You are able to sort and find drugs according to targeted signaling pathway from drop-down menu in the application.
Mechanism In total there are at least 90 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
- Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
- Drug Name & Synonyms
- Presentation of drug name and synonyms (if any)
Principal Investigator & Partners
Presentation of principal investigator and partners (if any)
- Target and Molecular Function of Target
- Described target(s) is/are presented with:
- Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
- Target Expression Profiles
- Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Targeted Signaling Pathways
Described target(s) is/are matched for the involvement in 20 major signaling pathways.
Mechanism
Drug mechanism of action
- Developmental Projects
- Summary field of developmental projects for the drug, including indication, developmental stage and status.
- Example:
- Cancer, myeloma - Phase II Clinical Trial - Active
- Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight
Patent Data
Available patent information related to the drug is presented here.
- Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Licensing Information
Availability for licensing
Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
- Drug status
- Clinical Trial Status
- Principle Investigator
- Partners
- Indication
- Developmental Stage
- Compound Type
- Mechanism
- Target
- Molecular Function of Target
- Target Localization
- Targeted Signaling Pathways
- Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Target data is linked directly to Human Protein Atlas
- Direct links to company web pages of principal investigators
Export and sharing of information
- Found information is easily shared with others over e-mail, file export (xls) or in print
System Requirements - AMD-Athlon/Pentium II PC
- Windows 98/NT4/2000/ME/XP
- 8x-speed CD Rom drive
- SVGA 16 bit display. (32 bit recommended)
- 32 MB of available RAM (128 MB recommended)
- Internet access (for related internet resources)
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