Home | Publications | Diagnostics place holder
place holder place holder

Diagnostics

Dermal Absorption and Toxicity Assessment


Publication Date   August 2007
Publisher   Informa Healthcare
Product Type   Book
Pages   600
ISBN Number   978-0-8493-7591-0
Product Code   IFH073
Ask a question about this product?

Price £130.00

approximately: $193 | €153

Summary


Written by internationally recognized experts in the field of dermal absorption and toxicity assessment, this source supplies a state-of-the-art overview of the dermal absorption process. Divided into six sections covering skin structure and absorption, measurement of absorption, modeling of dermal absorption and risk assessment, skin toxicity and its prevention, regulatory issues and specific examples of the absorption of environmental materials, this guide covers the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity, including alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory approval.

Content


  • Human Skin Morphology and Dermal Absorption
  • Animal Skin Morphology and Dermal Absorption
  • Skin Barrier Properties and Absorption
    • The Physical Structure of The Skin Barrier
    • Skin Lipid Morphology and Function
    • The Biosensor Properties of The Stratum Corneum
    • Immunological, Inflammatory and Other Consequences
    • Dermal Metabolism
    • Formulation Issues
    • The Role of Dermal Blood Flow, Lymphatics and Dermal Binding in Skin Absorption
  • Measurement of Skin Absorption
    • Investigation of Skin Permeation in Vitro and in Vivo
    • Use of Skin Equivalents for Dermal Absorption and Toxicity
    • Assessment of Skin Absorption Using Skin Stripping
    • Imaging Skin Absorption by Spectroscopic Methods
    • Measuring Transport into Follicles and Skin Appendages Relative to Stratum Corneum
  • Modeling of Dermal Absorption and Risk Assessment
    • Biophysical Models for Skin Transport and Absorption
    • Mathematical Models for Different Exposure Conditions
    • Flux and Maximum Flux or Permeability Coefficient
    • Physicochemical Determinants of Stratum Corneum Permeation
    • Modelling Skin Permeability in Risk Assessment
    • in Vitro-in Vivo Correlations in Transdermal Drug Delivery
    • Estimation of Subsequent Systemic Exposure - Physiological Models
    • Skin Pharmacodynamics and Pharmacokinetics
  • Riskofderm - Predictions Based on in Vivo Factors
  • Skin Toxicity and Prevention
    • Quantitative Structure Activity Relationships for Skin Corrosivity and Toxicity Skin Irritation and Hypersensitivity Reactions
    • Irritancy of Topical Chemicals and Transdermal Delivery Systems
    • Phototoxicity, Photocarcinogenicity and Photogenicity Systemic Toxicity in Man Secondary to Percutaneous Absorption
    • Effects of Solvents and Other Vehicles on The Stratum Corneum and Other Skin Components
    • Skin Protection - The Use of Protective Clothing and Formulation Strategies
  • Regulatory Issues
    • Usepa Perspectives on Skin Toxicity and Absorption
    • Current European Guidelines and Moving to Alternatives to Animal Testing