Ion Channel Trends 2007

Summary

This market report summarizes the results of HTStec's fourth annual global Pharma and Biotech web-based benchmarking survey on ion channels carried out in June 2007. The objectives of the 2007 study were to better understand the role of selectivity profiling of ion channels in drug discovery and drug safety assessment; the importance and study of cardiac liability testing and cardiotoxicity assessment; and the requirements for outsourced services based on these activities.

Examples of the areas the survey looked at are: interest in different classes of ion channels; number of ion channel primary targets or programs; technologies used to study ion channels; reasons for and the use of a check list in selectivity profiling where it is initiated and who are the key decision makers; most important factors in choosing a fee-for-service provider for screening ion channels; interest in outsourcing such screening; approach to cardiac liability testing and interest in outsourcing; systems used to asses in vitro cardiotoxicity, main challenges to its effective application and interest in outsourcing.

Contents

• Executive Summary
• Survey Methodology
• Lab Origin of Survey Respondents
• Geographic Origin of Survey Respondents
• Organisational Origin of Survey Respondents
• Respondent Breakdown by Lab Origin & Organisation
• Makeup of Survey Groupings Used for Data Analysis
• Job Role of Survey Respondents
• Classes of Ion Channels of Most Interest to Respondents
• Number of Ion Channel Targets or Drug Discovery Programs under Investigation
• Technologies Used To Study Ion Channel Targets In Drug Discovery
• Ion Channel-Related Activities Undertaken In House
• Ion Channel Primary Screening Metrics
• Source of Ion Channel Cell Lines & Interest in Pre-Aliquoted Cells
• Use of Membrane Preparations of Ion Channels for Ligand Binding Studies
• Reasons Given For Undertaking Counterscreens & Selectivity Profiling
• Use of a Selectivity Profile Check List against Different Target Classes
• Where Selectivity Profiling Against Ion Channels is Initiated
• Selectivity Profiling Decision Makers
• Main Factors for Choosing a Fee-For-Service Provider for Ion Channel Drug Discovery
• Summary of Survey Findings (1)
• Interest in Outsourcing Ion Channel Screening for Drug Discovery (1)
• Interest in Outsourcing Ion Channel Screening for Drug Discovery (2)
• Respondents Feedback on the Use of Functional Assays in Screening Ion Channels for Drug Discovery, & What is Needed for More Routine Use
• Usefulness of a Panel (Catalog) of Ion Channel Expressing Cell lines to In House Drug Discovery
• Interest in Profiling Agonists and/or Antagonists against a Large Panel (Catalog) of Ion Channel-Expressing Cell Lines to Assess Selectivity and or Specificity
• How Respondents Would Select Ion Channels from an Extensive Panel
• Respondent''s Approach to Cardiac Liability (hERG) Testing (1)
• Respondent''s Approach to Cardiac Liability (hERG) Testing (2)
• Main Factors for Choosing a Fee-For-Service Provider for Ion Channel Cardiac Liability Testing
• Interest in Outsourcing Cardiac Liability Testing (1)
• Interest in Outsourcing Cardiac Liability Testing (2)
• Summary of Survey Findings (2)
• Systems Respondent''s are using for In Vitro Cardiotoxicity Assessment
• How Respondents Rate the Value of In Vitro Cardiotoxicity Assessment for Safety Evaluation
• Drug Discovery Stages Applying In Vitro Cardiotoxicity Assessment
• Most Significant Challenges to In Vitro Cardiotoxicity Assessment
• Expected Price of Outsourced In Vitro Cardiotoxicity Assessment
• Expected Usage of Outsourced In Vitro Cardiotoxicity Assessment
• Interest in Some Outsourced Safety Assessment Services
• Other Systems that Respondent Would Screen an Ion Channel Panel for Safety Assessment
• Interest in Fee-For-Service Ion Channel Panels & Ion Channels of Interest
• Most Trusted & Most Used Fee-For-Service Providers (1)
• Most Trusted & Most Used Fee-For-Service Providers (2)
• Respondent''s Budget Outsourced Ion Channel Services (1)
• Respondent''s Budget Outsourced Ion Channel Services (2)
• Global Market Estimate for Outsourced Ion Channel Testing (1)
• Global Market Estimate for Outsourced Ion Channel Testing (2)
• Summary of Survey Findings (3)