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Biotechnology

Pharmaceutical Biotechnology

Drug Discovery and Clinical Applications

Publication Date   February 2004
Publisher   Wiley
Product Type   Book
Pages   336
ISBN Number   3-527-30554-8
Product Code   WIL001
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Price £115.00

approximately: $215 | €146

Summary


With its focus on industrial pharmaceutical research, written by international experts from the industry, this book fills in a gap in the existing literature. It reflects the combination of such pharmaceutical interests as drug delivery, drug targeting, quality and safety management, drug approval and regulation, patenting issues and biotechnology fundamentals. Thus it provides practitioners in pharmaceutical biotechnology with all the relevant information from the shelf.
The first part offers a comprehensive survey and review of the rapidly increasing array of biopharmaceuticals derived from the molecular biological approaches now widely available. This is followed by an extra section devoted to the very critical patenting and drug regulation issues. The whole is rounded off by detailed monographs of biotechnologically developed drugs that are already on the market.

Content


List of Contributors.
Color Plates.

Part I. Introduction to Concepts and Technologies in Pharmaceutical Biotechnology.

1. A Primer on Pharmaceutical Biotechnology and Industrial Applications (Oliver Kayser, Rainer H. Mller).
2. Procaryotic and Eucaryotic Cells in Biotech Production (Stefan Pelzer, Dirk Hoffmeister, Irmgard Merfort, Andreas Bechthold).
3. Biopharmaceuticals Expressed in Plants (Jrg Knblein

Part II. Industrial Development and Production Process.

4. Scientific, Technical and Economic Aspects of Vaccine Research and Development (Jens-Peter Gregersen).
5. DNA Vaccines: from Research Tools in Mice to Vaccines for Humans (Jeffrey Ulmer, John Donnelly, Jens-Peter Gregersen).
6. Characterization and Bioanalytical Aspects of Recombinant Proteins as Pharmaceutical Drugs (Jutta Haunschild, Titus Kretzschmar).
7. Biogeneric Drugs (Walter Hinderer).

Part III. Therapeutic Proteins - Special Pharmaceutical Aspects.

8. Pharmacokinetics and Pharmacodynamics of Biotech Drugs (Bernd Meibohm, Hartmut Derendorf).
9 Formulation of Biotech Products (Ralph Lipp, Erno Pungor).
10. Patents in the Pharmaceutical Biotechnology Industry: Legal and Ethical Issues (David B. Resnik).
11. Drug Approval in the European Union and the United States (Gary Walsh).

Part IV. Biotech 21 - Into the Next Decade.

12. Rituximab: Clinical Development of the First Therapeutic Antibody for Cancer (Antonio J. Grillo-Lpez).
13. Somatic Gene Therapy - Advanced Biotechnology Products in Clinical Development (Matthias Schweizer, Egbert Flory, Carsten Muenk, Klaus Cichutek, Uwe Gottschalk).
14. Nonviral Gene Transfer Systems in Somatic Gene Therapy (Oliver Kayser, Albrecht F. Kiderlen).
15. Xenotransplanation in Pharmaceutical Biotechnology (Gregory J. Brunn, Jeffrey L. Platt).
16. Sculpturing the Architecture of Mineralized Tissues: Tissue Engineering of Bone from Soluble Signals to Smart Biomimetic Matrices (Ugo Ripamonti, Lentsha Nathaniel Ramoshebi, Janet Patton, June Teare, Thato Matsaba, Louise Renton).
Index.